Effect of increasing concentrations of protein L, protein A, and anti-IgE on histamine release and de novo synthesis of LTC4 from HHMC
| Protein or antibody | Mean ± SEM | |
|---|---|---|
| % Histamine release | LTC4 (ng/106mast cells) | |
| Protein L (nM) | ||
| 10 | 2.2 ± 1.0 | 6.0 ± 1.7 |
| 30 | 13.2 ± 1.9 | 10.6 ± 3.4 |
| 100 | 19.2 ± 2.7 | 23.0 ± 3.1 |
| Protein A (nM) | ||
| 60 | 1.0 ± 0.4 | 3.0 ± 1.3 |
| 200 | 7.2 ± 1.2 | 13.6 ± 2.1 |
| 600 | 12.4 ± 1.4 | 21.2 ± 3.3 |
| Anti-IgE (μg/ml) | ||
| 0.3 | 2.2 ± 1.0 | 3.6 ± 1.0 |
| 1 | 11.6 ± 3.3 | 18.6 ± 3.9 |
| 3 | 15.0 ± 2.5 | 15.8 ± 3.2 |