Table 1.

Effect of increasing concentrations of protein L, protein A, and anti-IgE on histamine release and de novo synthesis of LTC4 from HHMC

Protein or antibodyMean ± SEM
% Histamine releaseLTC4 (ng/106mast cells)
Protein L (nM)
 102.2 ± 1.06.0 ± 1.7
 3013.2 ± 1.910.6 ± 3.4
 10019.2 ± 2.723.0 ± 3.1
Protein A (nM)
 601.0 ± 0.43.0 ± 1.3
 2007.2 ± 1.213.6 ± 2.1
 60012.4 ± 1.421.2 ± 3.3
Anti-IgE (μg/ml)
 0.32.2 ± 1.03.6 ± 1.0
 111.6 ± 3.318.6 ± 3.9
 315.0 ± 2.515.8 ± 3.2