TABLE 1.

LD50 of Y. pestis KIM5 in the presence of anti-LcrV or anti-YopM antibody in C57BL/6 and IL-10−/− mice

Mouse strainGrowth condition(s)Anti-LcrVaAnti-YopMa
C57BL/626°C1 × 106 ± 1 × 106 (n = 2)b
26/37°C4 × 105 ± 2 × 105 (n = 3)
B6.129P2-Il10tm1Cgn/J26°C2 × 106 ± 0.5 × 106 (n = 2)6 × 105 (n = 1)
26/37°C1 × 106 ± 1 × 106 (n = 2)4 × 105 ± 0.5 × 105 (n = 2)
  • a Groups of 4 mice were given a single dose of 100 μg of antibody the day before infection with Y. pestis KIM5 grown as indicated. Values are averages ± standard deviations or range from three or two replicate experiments, respectively. The number of experiments (n) is given in parentheses.

  • b A third experiment gave an LD50 of >106.