TABLE 3.

Macroscopic lung pathology after intratracheal P. aeruginosa challenge of CF mice and BALB/c mice with the mucoid strain +QS (NH57388A), the nonmucoid strain −QS (NH57388B), and the nonmucoid strain +QS (NH57388C)a

ScorecPathology (no. of mice in scoring groups/total no. of mice challenged [%]) at day 7
Expt 1Expt 2Expt 3Expt 4
CF mice (mucoid +QS*** NH57388A)BALB/c mice (mucoid +QS NH57388A)BALB/c mice (mucoid +QS**** NH57388A)BALB/c mice (nonmucoid −QS NH57388B)BALB/c mice (mucoid +QS* NH57388A)BALB/c mice (mucoid + QS NH57388A)bCF mice (mucoid +QS NH57388A)CF mice (nonmucoid +QS** NH57388C)CF mice (nonmucoid −QS***** NH57388B)
11/15 (7)5/12 (42)1/9 (11)
210/15 (67)7/12 (58)2/6 (33)1/7 (14)6/6 (100)8/9 (89)
32/9 (22)3/15 (20)4/10 (40)8/10 (80)2/6 (33)2/7 (29)
47/9 (78)1/15 (7)6/10 (60)2/10 (20)2/6 (33)4/7 (57)
  • a See Table 2, footnote a. Asterisks indicate probabilities as follows: *, P < 0.01 compared to day 13; **, P < 0.01 compared to the mucoid strain NH57388A +QS; ***, P < 0.001 compared to BALB/c mice; ****, P < 0.001 compared to the nonmucoid strain NH57388B −QS; *****, P < 0.001 compared to the mucoid strain NH57388A +QS.

  • b Day 13, in this case.

  • c Score 1, normal; 2, swollen lungs, hyperemia, small atelectasis; 3, pleural adhesion, atelectasis, multiple small abscesses; 4, large abscesses, large atelectasis, and hemorrhages.