TABLE 1.

Predominant immune genes up-regulated by TSST-1 and S. aureus strains MNSM and MN8

Gene productFold change from control
TSST-1 (100 μg/ml)MNSMMN8 (6 h)
3 h6 h3 h6 h
CCL20 (MIP-3α)a168.9207.9477.7274.4
CXCL1 (GRO-α)16.084.426.017.121.1
CXCL2 (GRO-β)4.913.013.913.027.9
CXCL3 (GRO-γ)4.032.029.919.714.9
CXCL14 (BRAK/bolekine)12.15.3
Colony-stimulating factor 2 (granulocyte-macrophage)18.4119.4
Colony-stimulating factor 3 (granulocyte)11.34.3
IL-1α3.24.67.07.5
IL-1β2.02.14.06.1
IL-62.38.64.92.8
IL-88.048.511.313.964.0
IL-154.39.82.1
Lymphotoxin-β (TNF-β)2.14.65.3
MHC class I-A2.1
MHC class I-B2.3
MHC class I-C3.2
MHC class I-F2.16.12.3
MHC class I-G2.0
Pentaxin-related geneb27.932.016.0
TNF-α2.57.510.62.5
  • a —, no significant change from control. Significant genes were definitively present and statistically determined to be up- or down-regulated by ≥2-fold.

  • b Related to C-reactive protein.