TABLE 3.

Intranasal LVS vaccination induced specific protection against i.n. challenge of F. tularensis but not Y. pestis

Expt no.Vaccination statusChallenge organismSurvival (no. of survivors/no. tested)Mean time to death (days)
1aNoneLVS0/46.5
LVSLVS4/4
NoneNMFTA10/45.5
LVSNMFTA14/4
2bNoneNMFTA10/45.0
LVSNMFTA13/3
NoneY. pestis0/44.0
LVSY. pestis0/44.0
3cNoneY. pestis0/103.2
LVSY. pestis0/103.6
  • a Vaccinated BALB/c mice were challenged i.n. with 5 × 104 CFU of LVS or 2 × 102 CFU of NMFTA1. The results show survival ratios on day 16 postinfection.

  • b Vaccinated BALB/c mice were challenged i.n. with 2 × 102 CFU of NMFTA1 or 104 CFU of Y. pestis. The results show survival ratios on day 26 postinfection.

  • c Vaccinated BALB/c mice were challenged i.n. with 104 CFU of Y. pestis and were monitored until death.