TABLE 1.

Metastatic infections in different organs by S. epidermidis strains in the rat CVC-associated infection model

Parameter and organResult for straina:
ATCC 12228ATCC 12228-icaHBHB-icaTü3298Tü3298-ica
Liver
    No. of rats infected/ total3/107/102/68/86/97/9
    Median (range) CFU/g tissue0 (0 × 102-1.3 × 102)1.7 × 103 (0 × 105-2.7 × 105)1.7 (0 × 102-1 × 102)3.8 × 102 (3.3 × 101-6.2 × 103)3.3 × 102 (0 × 104-4 × 104)1 × 103 (0 × 104-8.3 × 104)
    P value0.0190.00780.1631
Kidney
    No. of rats infected/ total2/107/102/68/85/96/9
    Median (range) CFU/g tissue0 (0 × 102-2.3 × 102)2.7 × 102 (0 × 107-1.3 × 107)2.5 × 101 (0 × 102-8.5 × 102)2.6 × 103 (3.0 × 102-3.3 × 104)6.7 × 102 (0 × 105-3.2 × 105)4.3 × 103 (0 × 106-2.7 × 106)
    P value0.0150.00660.7502
Heart
    No. of rats infected/ total3/107/101/66/84/97/9
    Median (range) CFU/g tissue0 (0 × 102-3.6 × 102)3.8 × 102 (0 × 104-7.2 × 104)5 (0 × 101-8.3 × 101)2.0 × 102 (0 × 103-7.2 × 103)0 (0 × 103-2.7 × 103)2.3 × 103 (0 × 104-2.9 × 104)
    P value0.0230.06450.0792
Blood
    No. of rats infected/ total4/106/100/67/82/95/9
    Median (range) CFU/g tissue0 (0 × 102-1.3 × 102)1.5 × 102 (0 × 102-4.9 × 102)0 (0-0)8.6 × 102 (0 × 103-1.75 × 103)0 (0 × 102-6.0 × 102)10 (0 × 103-8.0 × 103)
    P value0.1230.00370.2649
Infection
    Infection rate (%)30.0 ± 8.267.5 ± 5.020.8 ± 16.090.6 ± 20.047.2 ± 19.069.4 ± 10.6
    P value<0.0001<0.00010.056
  • a For statistical significance (Wilcoxon test), results represent animals challenged with S. epidermidis ATCC 12228, HB, or Tü3298 versus those challenged with S. epidermidis ATCC 12228-ica, HB-ica, or Tü3298-ica.