TABLE 1.

Syphilitic lesion development following intradermal challenge of passively immunized rabbitsa

Immunization mediumNo. of lesions/ no. of sitesRangec (days)Mean ± SE
DaysLesion diamd (mm)
NRS24/241111 ± 012.8 ± 0.52
IRS24/2412-1713.2 ± 0.373.7 ± 0.36
C MAbb24/2412-1513.2 ± 0.2312.3 ± 0.36
M13117/2418-2821.1 ± 0.75e3.5 ± 0.33
  • a Groups of three rabbits were passively immunized with the indicated sera or MAb at 18 h before challenge, the day of challenge, and 72 h postchallenge. Each animal was challenged intradermally with 103T. pallidum cells at each of eight sites.

  • b C MAb, control MAb.

  • c Range represents the day to first detection of erythematous and indurated lesions.

  • d Mean lesion diameter was determined at 25 days postchallenge.

  • e P < 0.001, compared with the results of the control MAb and NRS.