TABLE 1.

Hematologic changes observed 26 h after CLPa

Parameter and groupNormalSham operated25-Gc single puncture25-G double puncture21-G puncture
WBCb (103/μl)
    WT10.9 ± 3.79.7 ± 1.64.2 ± 1.4 5.5 ± 0.4 6.8 ± 0.6
    IL-6KO13.2 ± 1.18.6 ± 1.74.5 ± 1.1 2.9 ± 0.2 3.7 ± 0.4
Lymphocytes (103/μl)
    WT9.3 ± 3.27.1 ± 1.42.6 ± 1.0 4.0 ± 0.3 5.4 ± 0.4
    IL-6KO9.5 ± 0.76.7 ± 1.62.6 ± 0.8 1.6 ± 0.2 2.5 ± 0.4
Neutrophils (103/μl)
    WT 1.2 ± 0.6 2.1 ± 0.51.3 ± 0.71.1 ± 0.11.1 ± 0.2
    IL-6KO 3.1 ± 0.4 1.4 ± 0.21.5 ± 0.61.0 ± 0.11.0 ± 0.2
Hemoglobin (g/dl)
    WT12.8 ± 2.211.8 ± 0.910.5 ± 1.4 12.1 ± 0.4 11.9 ± 0.8
    IL-6KO13.0 ± 0.311.5 ± 1.010.9 ± 1.3 9.8 ± 0.7 11.5 ± 0.9
Platelets (106/μl)
    WT877 ± 270919 ± 95570 ± 179 433 ± 51 434 ± 58
    IL-6KO880 ± 30820 ± 63422 ± 190 287 ± 30 381 ± 38of
  • a Values which are statistically significantly different between the wild type and KO are listed in bold. Each value is the mean ± the standard error of the mean (n = 15 for normal mice, n = 6 for sham-operated mice, n = 19 for 25-gauge single puncture, n = 14 for 25-gauge double puncture, and n = 4 for 21 gauge).

  • b WBC, white blood cells.

  • c G, gauge.