TABLE 1.

ELISA antibody values in sera from volunteers on selected days postvaccination

Volunteer no.Vaccine dose (μg)ELISA value for plate antigen:
AMA1-3D7AMA1-FVO
Day 0Day 42Day 194Day 364Day 0Day 42Day 194Day 364
150a0161220019031
20093190329229
300192120016917
40021553009338
5021117611008911292
600911200160
700311200420
800721200570
9068218480017929
1000281770017953
Meanb ± SE028 ± 21153 ± 2538 ± 11012 ± 9113 ± 2029 ± 9
1220002188903617378
130000002313
1402571,76017103331,192143
150537291880101568216
16004318005522
170535001140035379
1802112,00022701121,272200
1901,4404,08423501,0602,816355
200016000160
Mean ± SE0203 ± 140937 ± 419105 ± 300165 ± 105649 ± 284111 ± 37
2180077NAcNA058NANA
22000NA009NA
230673772708941426
2404491,68833302871,496239
2505122,86410904551,568116
260322672NA0269944NA
27029425744034726846
28063NA380108NA60
290140NANA033NANA
Mean ± SE0206 ± 56897 ± 38697 ± 490175 ± 48712 ± 23787 ± 33
  • a Samples with ELISA values below the limit of detection in the assay were assigned a value of 0.

  • b For calculation of arithmetic mean values, samples with less than the minimum detectable concentration were assigned a value of zero.

  • c NA, not available.