TABLE 1.

Shared pattern of differentially expressed macrophage genes in response to M. avium strains TMC724, 2151SmT, 2151SmO, and SE01

CategoryGene name (UniGene)DesignationFold regulation ina
TMC7242151SmT2151SmOSE01
CytokinesInterleukin 1, betaIL-1b7.4115.5119.8716.02
Interleukin 6 (interferon, beta 2)IL-668.83264.55489.99306.51
Tumor necrosis factorTNF4.583.763.8910.02
TNF superfamily, member 29.0810.0713.3217.24
Lymphotoxin alpha TNF superfamily member 1LTA4.583.763.8910.02
ChemokinesInterleukin 8IL-82.914.214.504.07
Small inducible cytokine A5RANTES4.3619.0221.8620.20
GRO1 oncogeneMGSA36.5563.1081.2775.78
GRO2 oncogeneMIP-2A11.3215.5719.9318.96
GRO3 oncogeneMIP-2B11.6115.0017.3621.64
Small inducible cytokine A2MCP-12.554.215.093.69
Monocyte chemotactic protein 12.854.535.123.98
Small inducible cytokine A3MIP-1A3.084.194.714.76
Small inducible cytokine A4MIP-1B8.1611.1012.3111.63
Small inducible cytokine subfamily A (Cys-Cys), member 20MIP-3A24.4370.86114.24132.60
ReceptorsAdenosine A2a receptorADORA2A12.379.4412.8013.95
Interleukin 7 receptorIL-7R3.204.095.375.29
Tumor necrosis factor receptor superfamily, member 4TNFRSF42.814.585.015.58
Chemokine (C-C motif) receptor 2CCR2−5.01−6.84−6.56−16.20
Chemokine (C-X-C motif), receptor 4 (fusin)CXCR4−3.94−4.35−4.79−11.98
Signal transductionNef-associated factor 1NAF12.412.503.022.72
TNF receptor-associated factor 1TRAF14.836.868.158.40
Jagged 1 (Alagille syndrome)JAG13.594.515.036.76
Phosphodiesterase 4B, cAMP specificPDE4B2.964.294.323.40
Thyroid hormone receptor interactor 10TRIP102.964.065.607.17
Seven in absentia (Drosophila) homolog 2SIAH22.412.882.663.95
CytoskeletonSinged (Drosophila)-like (sea urchin fascin homolog-like)SNL3.658.0611.9012.74
TranscriptionNuclear factor of kappa light polypeptideLYT-102.192.483.023.44
Gene enhancer in B-cells 2 (p49/p100)LOC1253873.462.914.835.03
Butyrate response factor 2 (EGF-resp. factor 2)BRF2−2.41−4.23−6.44−8.55
EnzymesAdenosine deaminaseADA2.313.765.786.12
Prostaglandin-endoperoxide synthase 2PTGS227.2927.6854.59153.21
GTP cyclohydrolase 1 (dopa-responsive dystonia)GCH14.327.6810.219.51
Carbohydrate (chondroitin 6/keratan)C6ST2.462.523.023.28
Sulfotransferase 2
AntiapoptosisTumor necrosis factor, alpha-induced protein 3TNFAIP33.063.203.654.09
Immediate early response 3IER33.383.984.344.66
AdhesionIntercellular adhesion molecule 1 (CD54), human rhinovirus receptorICAM12.993.644.064.25
Tumor necrosis factor, alpha-induced protein 6TNFAIP65.6211.8016.5317.93
Proliferation/ cell cycleTumor necrosis factor receptor superfamily, member 9TNFRSF92.873.794.423.48
Tumor necrosis factor (ligand) superfamily, member 9TNFSF913.9213.8427.9997.96
Putative lymphocyte G0/G1 switch geneGOS23.073.043.203.95
Pim-2 oncogenePIM22.623.554.444.51
ClottingGlycoprotein 1b (platelet), alpha polypeptideGP1B3.064.003.673.99
MiscellaneousTumor necrosis factor alpha-induced protein 2TNFAIP23.685.025.906.61
Tumor suppressing subtransferable candidate 3TSSC32.293.114.224.59
Myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)MACS2.392.872.913.24
AdrenomedullinADM3.813.744.788.82
Pentaxin-related, rapidly induced by IL-1betaPTX312.7839.59106.07120.67
EH domain containing 1EHD13.314.275.766.14
KIAA0854 proteinKIAA08542.232.713.224.49
Wilms' tumor 1-associating proteinKIAA01052.813.554.454.62
Hypothetical proteinFLJ205002.836.626.515.05
Human DNA sequence from clone RP5-1174N9 on chromosome 1p34.1-35.33.443.032.934.25
  • a Positive values indicate fold induction, and negative values indicate fold suppression.