TABLE 3.

Susceptibilities of M. catarrhalis wild-type strain O35E and mutant O35EkdtA to a panel of hydrophobic agents or a hydrophilic glycopeptide

Compound (amt or concn)Zone of growth inhibition for strains (mm)a
O35EO35EkdtA
Azithromycin (15 μg)29.0 ± 0.535.4 ± 0.5
Fusidic acid (10 mg/ml)29.0 ± 0.932.5 ± 0.5
Novobiocin (5 μg)13.8 ± 0.316.1 ± 0.3
Polymycin B (300 iu)11.5 ± 0.515.5 ± 0.0
Rifampin (5 μg)22.1 ± 0.329.0 ± 0.5
Vancomycin (5 μg)<6.0b8.2 ± 0.3
Deoxycholate (100 mg/ml)22.0 ± 0.926.8 ± 0.3
Triton X-100 (5% [wt/vol])15.5 ± 0.524.5 ± 0.5
Tween 20 (5% [vol/vol])11.5 ± 0.514.2 ± 0.3
  • a Sensitivity was assessed by measuring the diameter of the zone of growth inhibition in two axes, and the mean value was calculated. Values are the means ± standard deviations. The data represent the averages of three separate experiments.

  • b Stands for no inhibition for bacterial growth.