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Infection and Immunity
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anemia

  • Failure of CD4 T Cell-Deficient Hosts To Control Chronic Nontyphoidal <em>Salmonella</em> Infection Leads to Exacerbated Inflammation, Chronic Anemia, and Altered Myelopoiesis
    Host Response and Inflammation
    Failure of CD4 T Cell-Deficient Hosts To Control Chronic Nontyphoidal Salmonella Infection Leads to Exacerbated Inflammation, Chronic Anemia, and Altered Myelopoiesis

    Immunocompromised patients are more susceptible to recurrent nontyphoidal Salmonella (NTS) bacteremia. A key manifestation of HIV infection is the loss of CD4 T cells, which are crucial for immunity to Salmonella infection. We characterized the consequences of CD4 T cell depletion in mice where virulent Salmonella establish chronic infection, similar to chronic NTS disease in humans. Salmonella-...

    Wendy P. Loomis, Martha A. Delaney, Matthew L. Johnson, Brad T. Cookson
  • Fungal and Parasitic Infections
    Clinical Outcomes of Submicroscopic Infections and Correlates of Protection of VAR2CSA Antibodies in a Longitudinal Study of Pregnant Women in Colombia
    Kenneth Gavina, Sedami Gnidehou, Eliana Arango, Chloe Hamel-Martineau, Catherine Mitran, Olga Agudelo, Carolina Lopez, Aisha Karidio, Shanna Banman, Jaime Carmona-Fonseca, Ali Salanti, Nicaise Tuikue Ndam, Michael Hawkes, Amanda Maestre, Stephanie K. Yanow
  • Fungal and Parasitic Infections
    A Novel Functional Variant in the Stem Cell Growth Factor Promoter Protects against Severe Malarial Anemia
    Collins Ouma, Christopher C. Keller, Gregory C. Davenport, Tom Were, Stephen Konah, Michael F. Otieno, James B. Hittner, John M. Vulule, Jeremy Martinson, John M. Ong'echa, Robert E. Ferrell, Douglas J. Perkins
  • Fungal and Parasitic Infections
    Suppression of a Novel Hematopoietic Mediator in Children with Severe Malarial Anemia
    Christopher C. Keller, Collins Ouma, Yamo Ouma, Gordon A. Awandare, Gregory C. Davenport, Tom Were, James B. Hittner, John M. Vulule, John M. Ong'echa, Douglas J. Perkins
  • Molecular Pathogenesis
    Gamma Interferon Suppresses Erythropoiesis via Interleukin-15
    Isis K. Mullarky, Frank M. Szaba, Lawrence W. Kummer, Lindsey B. Wilhelm, Michelle A. Parent, Lawrence L. Johnson, Stephen T. Smiley
  • Fungal and Parasitic Infections
    Role of Monocyte-Acquired Hemozoin in Suppression of Macrophage Migration Inhibitory Factor in Children with Severe Malarial Anemia
    Gordon A. Awandare, Yamo Ouma, Collins Ouma, Tom Were, Richard Otieno, Christopher C. Keller, Gregory C. Davenport, James B. Hittner, John Vulule, Robert Ferrell, John M. Ong'echa, Douglas J. Perkins
  • Fungal and Parasitic Infections
    Schistosoma japonicum Reinfection after Praziquantel Treatment Causes Anemia Associated with Inflammation
    Tjalling Leenstra, Hannah M. Coutinho, Luz P. Acosta, Gretchen C. Langdon, Li Su, Remigio M. Olveda, Stephen T. McGarvey, Jonathan D. Kurtis, Jennifer F. Friedman
  • Fungal and Parasitic Infections
    Acquisition of Hemozoin by Monocytes Down-Regulates Interleukin-12 p40 (IL-12p40) Transcripts and Circulating IL-12p70 through an IL-10-Dependent Mechanism: In Vivo and In Vitro Findings in Severe Malarial Anemia
    Christopher C. Keller, Ouma Yamo, Collins Ouma, John Michael Ong'echa, David Ounah, James B. Hittner, John M. Vulule, Douglas J. Perkins
  • Fungal and Parasitic Infections
    Levels of Plasma Immunoglobulin G with Specificity against the Cysteine-Rich Interdomain Regions of a Semiconserved Plasmodium falciparum Erythrocyte Membrane Protein 1, VAR4, Predict Protection against Malarial Anemia and Febrile Episodes
    John P. A. Lusingu, Anja T. R. Jensen, Lasse S. Vestergaard, Daniel T. Minja, Michael B. Dalgaard, Samwel Gesase, Bruno P. Mmbando, Andrew Y. Kitua, Martha M. Lemnge, David Cavanagh, Lars Hviid, Thor G. Theander
  • Fungal and Parasitic Infections
    Elevated Nitric Oxide Production in Children with Malarial Anemia: Hemozoin-Induced Nitric Oxide Synthase Type 2 Transcripts and Nitric Oxide in Blood Mononuclear Cells
    Christopher C. Keller, Peter G. Kremsner, James B. Hittner, Mary A. Misukonis, J. Brice Weinberg, Douglas J. Perkins

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