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antibiotics

  • Outer Membrane Lipid Secretion and the Innate Immune Response to Gram-Negative Bacteria
    Minireview
    Outer Membrane Lipid Secretion and the Innate Immune Response to Gram-Negative Bacteria

    The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The asymmetric character and unique biochemistry of LPS molecules contribute to the OM’s ability to function as a molecular permeability barrier that protects the bacterium against hazards in the environment. Assembly and regulation of the OM have been extensively...

    Nicole P. Giordano, Melina B. Cian, Zachary D. Dalebroux
  • Role of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Glutathione Biosynthesis in Lung and Soft Tissue Infection
    Bacterial Infections
    Role of Pseudomonas aeruginosa Glutathione Biosynthesis in Lung and Soft Tissue Infection

    The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of morbidity and mortality worldwide. To survive in both the environment and the host, P. aeruginosa must cope with redox stress. In P. aeruginosa, a primary...

    Kelly L. Michie, Justine L. Dees, Derek Fleming, Dina A. Moustafa, Joanna B. Goldberg, Kendra P. Rumbaugh, Marvin Whiteley
  • Open Access
    Antibiotic-Induced Shifts in Fecal Microbiota Density and Composition during Hematopoietic Stem Cell Transplantation
    Host-Associated Microbial Communities | Spotlight
    Antibiotic-Induced Shifts in Fecal Microbiota Density and Composition during Hematopoietic Stem Cell Transplantation

    Dramatic microbiota changes and loss of commensal anaerobic bacteria are associated with adverse outcomes in hematopoietic cell transplantation (HCT) recipients. In this study, we demonstrate these dynamic changes at high resolution through daily stool sampling and assess the impact of individual antibiotics on those changes.

    Sejal Morjaria, Jonas Schluter, Bradford P. Taylor, Eric R. Littmann, Rebecca A. Carter, Emily Fontana, Jonathan U. Peled, Marcel R. M. van den Brink, Joao B. Xavier, Ying Taur
  • Host Response and Inflammation
    Lactobacillus rhamnosus L34 Attenuates Gut Translocation-Induced Bacterial Sepsis in Murine Models of Leaky Gut
    Wimonrat Panpetch, Wiwat Chancharoenthana, Kanthika Bootdee, Sumanee Nilgate, Malcolm Finkelman, Somying Tumwasorn, Asada Leelahavanichkul
  • Host Response and Inflammation
    Why Antibiotic Treatment Is Not Enough for Sepsis Resolution: an Evaluation in an Experimental Animal Model
    Jonathan L. Halbach, Andrew W. Wang, Dennis Hawisher, David M. Cauvi, Radhames E. Lizardo, Joseph Rosas, Tony Reyes, Omar Escobedo, Stephen W. Bickler, Raul Coimbra, Antonio De Maio
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