assay development
- Microbial Immunity and Vaccines | SpotlightStandardization of Pneumococcal Biofilm Release to PncO Expression, a Predictive Measurement of Virulence
A critical component in clinical trials for vaccines against pneumococcal disease is the establishment of robust preclinical models and clinical correlates of protection, which, in the case of the causative bacterial agent Streptococcus pneumoniae, include standard sepsis/pneumonia mouse models and opsonophagocytic activity (OPA), respectively. Despite broad usage,...