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Infection and Immunity
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bacteriophages

  • Open Access
    Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies
    Minireview
    Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies

    Bacteria that cause life-threatening infections in humans are becoming increasingly difficult to treat. In some instances, this is due to intrinsic and acquired antibiotic resistance, indicating that new therapeutic approaches are needed to combat bacterial pathogens. There is renewed interest in utilizing viruses of bacteria known as bacteriophages (phages) as potential antibacterial therapeutics. However, critics suggest that similar...

    Mihnea R. Mangalea, Breck A. Duerkop
  • Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci
    Host-Associated Microbial Communities | Spotlight
    Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci

    Enterococcus faecalis is a human intestinal pathobiont with intrinsic and acquired resistance to many antibiotics, including vancomycin. Nature provides a diverse and virtually untapped repertoire of bacterial viruses, or bacteriophages (phages), that could be harnessed to combat multidrug-resistant enterococcal infections.

    Anushila Chatterjee, Cydney N. Johnson, Phat Luong, Karthik Hullahalli, Sara W. McBride, Alyxandria M. Schubert, Kelli L. Palmer, Paul E. Carlson, Breck A. Duerkop
  • Bacterial Infections
    Filamentous Bacteriophage Produced by Pseudomonas aeruginosa Alters the Inflammatory Response and Promotes Noninvasive Infection In Vivo
    Patrick R. Secor, Lia A. Michaels, Kate S. Smigiel, Maryam G. Rohani, Laura K. Jennings, Katherine B. Hisert, Allison Arrigoni, Kathleen R. Braun, Timothy P. Birkland, Ying Lai, Teal S. Hallstrand, Paul L. Bollyky, Pradeep K. Singh, William C. Parks
  • Bacterial Infections
    Effect of Chlamydiaphage φCPG1 on the Course of Conjunctival Infection with “Chlamydia caviae” in Guinea Pigs
    Roger G. Rank, Anne K. Bowlin, Stefania Cané, Huizhong Shou, Zhi Liu, Uma M. Nagarajan, Patrik M. Bavoil
  • Molecular Pathogenesis
    Bacteriophage 2851 Is a Prototype Phage for Dissemination of the Shiga Toxin Variant Gene 2c in Escherichia coli O157:H7
    Eckhard Strauch, Jens Andre Hammerl, Antje Konietzny, Susanne Schneiker-Bekel, Walter Arnold, Alexander Goesmann, Alfred Pühler, Lothar Beutin
  • Bacterial Infections
    Effect of Phage on the Infectivity of Vibrio cholerae and Emergence of Genetic Variants
    M. Shamim Hasan Zahid, S. M. Nashir Udden, A. S. G. Faruque, Stephen B. Calderwood, John J. Mekalanos, Shah M. Faruque
  • Bacterial Infections
    A Listeria monocytogenes Mutant Defective in Bacteriophage Attachment Is Attenuated in Orally Inoculated Mice and Impaired in Enterocyte Intracellular Growth
    Patricia A. Spears, M. Mitsu Suyemoto, Angela M. Palermo, John R. Horton, Terri S. Hamrick, Edward A. Havell, Paul E. Orndorff
  • Molecular Pathogenesis
    Bacteriophage MAV1 Is Not Associated with Virulence of Mycoplasma arthritidis
    Brenda Clapper, Anh-Hue T. Tu, Warren L. Simmons, Kevin Dybvig
  • Bacterial Infections
    Diversity and Host Range of Shiga Toxin-Encoding Phage
    Shantini D. Gamage, Angela K. Patton, James F. Hanson, Alison A. Weiss
  • Molecular Pathogenesis
    In Vivo Lysogenic Conversion of Tox−Streptococcus pyogenes to Tox+ with Lysogenic Streptococci or Free Phage
    Thomas B. Broudy, Vincent A. Fischetti

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