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Infection and Immunity
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biofilms

  • A Nonfimbrial Adhesin of <em>Aggregatibacter actinomycetemcomitans</em> Mediates Biofilm Biogenesis
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    A Nonfimbrial Adhesin of Aggregatibacter actinomycetemcomitans Mediates Biofilm Biogenesis

    Periodontitis is an inflammatory disease caused by polymicrobial biofilms. The periodontal pathogen Aggregatibacter actinomycetemcomitans displays two proteinaceous surface structures, the fimbriae and the nonfimbrial extracellular matrix binding protein A (EmaA), as observed by electron microscopy.

    David R. Danforth, Gaoyan Tang-Siegel, Teresa Ruiz, Keith P. Mintz
  • Genomic, Phenotypic, and Virulence Analysis of <em>Streptococcus sanguinis</em> Oral and Infective-Endocarditis Isolates
    Molecular Genomics
    Genomic, Phenotypic, and Virulence Analysis of Streptococcus sanguinis Oral and Infective-Endocarditis Isolates

    Streptococcus sanguinis, an abundant and benign inhabitant of the oral cavity, is an important etiologic agent of infective endocarditis (IE), particularly in people with predisposing cardiac valvular damage. Although commonly isolated from patients with IE, little is known about the factors that make any particular...

    Shannon P. Baker, Tara J. Nulton, Todd Kitten
  • Microbial Immunity and Vaccines | Spotlight
    Standardization of Pneumococcal Biofilm Release to PncO Expression, a Predictive Measurement of Virulence

    A critical component in clinical trials for vaccines against pneumococcal disease is the establishment of robust preclinical models and clinical correlates of protection, which, in the case of the causative bacterial agent Streptococcus pneumoniae, include standard sepsis/pneumonia mouse models and opsonophagocytic activity (OPA), respectively. Despite broad usage,...

    A. Hill, M. Beitelshees, B. A. Pfeifer, C. H. Jones
  • Bacterial Infections
    Utilization of Variant and Fusion Proteins To Functionally Map the Aggregatibacter actinomycetemcomitans Trimeric Autotransporter Protein ApiA
    Carla Cugini, Yongyi Mei, David Furgang, Nisha George, Narayanan Ramasubbu, Daniel H. Fine
  • Microbial Immunity and Vaccines
    Oral Application of Recombinant Bacillus subtilis Spores to Dogs Results in a Humoral Response against Specific Echinococcus granulosus Paramyosin and Tropomyosin Antigens
    Cédric M. Vogt, Maria Teresa Armúa-Fernández, Kurt Tobler, Monika Hilbe, Claudio Aguilar, Mathias Ackermann, Peter Deplazes, Catherine Eichwald
  • Molecular Pathogenesis
    Small RNA teg49 Is Derived from a sarA Transcript and Regulates Virulence Genes Independent of SarA in Staphylococcus aureus
    Adhar C. Manna, Samin Kim, Liviu Cengher, Anna Corvaglia, Stefano Leo, Patrice Francois, Ambrose L. Cheung
  • Open Access
    Bacterial Infections
    Model of Chronic Equine Endometritis Involving a Pseudomonas aeruginosa Biofilm
    Ryan A. Ferris, Patrick M. McCue, Grace I. Borlee, Kristina E. Glapa, Kevin H. Martin, Mihnea R. Mangalea, Margo L. Hennet, Lisa M. Wolfe, Corey D. Broeckling, Bradley R. Borlee
  • Bacterial Infections
    Hyperbiofilm Formation by Bordetella pertussis Strains Correlates with Enhanced Virulence Traits
    Natalia Cattelan, Jamie Jennings-Gee, Purnima Dubey, Osvaldo M. Yantorno, Rajendar Deora
  • Letter to the Editor
    Reply to Brennan, “Biofilms and Mycobacterium tuberculosis”
    Georgiana E. Purdy
  • Letter to the Editor
    Biofilms and Mycobacterium tuberculosis
    Michael J. Brennan

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