bone resorption
Host Response and InflammationSilencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K SecretionEndodontic disease is characterized by inflammation and destruction of periapical tissues, leading to severe bone resorption and tooth loss. ATP6AP1 (Ac45) has been implicated in human immune diseases, yet the mechanism underlying how Ac45 regulates immune response and reaction in inflammatory diseases remains unknown. We generated endodontic disease mice through bacterial infection as an inflammatory disease model and used adeno-...
- Host Response and InflammationAnti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model
- Host Response and InflammationInvolvement of SOCS3 in Regulation of CD11c+ Dendritic Cell-Derived Osteoclastogenesis and Severe Alveolar Bone Loss
- Host Response and InflammationContribution of Interleukin-11 and Prostaglandin(s) in Lipopolysaccharide-Induced Bone Resorption In Vivo
- Host Response and InflammationInterleukin-6 Deficiency Increases Inflammatory Bone Destruction
- Host Response and InflammationToll-Like Receptor 4-Deficient Mice Have Reduced Bone Destruction following Mixed Anaerobic Infection
- MOLECULAR AND CELLULAR PATHOGENESISEffect of MALP-2, a Lipopeptide fromMycoplasma fermentans, on Bone Resorption In Vitro