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Infection and Immunity
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bone resorption

  • Silencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K Secretion
    Host Response and Inflammation
    Silencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K Secretion

    Endodontic disease is characterized by inflammation and destruction of periapical tissues, leading to severe bone resorption and tooth loss. ATP6AP1 (Ac45) has been implicated in human immune diseases, yet the mechanism underlying how Ac45 regulates immune response and reaction in inflammatory diseases remains unknown. We generated endodontic disease mice through bacterial infection as an inflammatory disease model and used adeno-...

    Wenbin Yang, Zheng Zhu, Longjiang Li, Abigail McVicar, Ning Gao, Lin Wang, Yi-Ping Li, Wei Chen
  • Host Response and Inflammation
    Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model
    Chiaki Yoshihara-Hirata, Keisuke Yamashiro, Tadashi Yamamoto, Hiroaki Aoyagi, Hidetaka Ideguchi, Mari Kawamura, Risa Suzuki, Mitsuaki Ono, Hidenori Wake, Masahiro Nishibori, Shogo Takashiba
  • Host Response and Inflammation
    Local Induction of B Cell Interleukin-10 Competency Alleviates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice
    Pei Yu, Yang Hu, Zhiqiang Liu, Toshihisa Kawai, Martin A. Taubman, Wei Li, Xiaozhe Han
  • Host Response and Inflammation
    Involvement of SOCS3 in Regulation of CD11c+ Dendritic Cell-Derived Osteoclastogenesis and Severe Alveolar Bone Loss
    Xiaoxia Zhang, Mawadda Alnaeeli, Bhagirath Singh, Yen-Tung A. Teng
  • Host Response and Inflammation
    Macrophage-Elicited Osteoclastogenesis in Response to Bacterial Stimulation Requires Toll-Like Receptor 2-Dependent Tumor Necrosis Factor-Alpha Production
    Takashi Ukai, Hiromichi Yumoto, Frank C. Gibson, Caroline Attardo Genco
  • Host Response and Inflammation
    Contribution of Interleukin-11 and Prostaglandin(s) in Lipopolysaccharide-Induced Bone Resorption In Vivo
    Li Li, Alireza Khansari, Lior Shapira, Dana T. Graves, Salomon Amar
  • Host Response and Inflammation
    Interleukin-6 Deficiency Increases Inflammatory Bone Destruction
    Khaled Balto, Hajime Sasaki, Philip Stashenko
  • Molecular Pathogenesis
    Impaired Bone Resorption by Lipopolysaccharide In Vivo in Mice Deficient in the Prostaglandin E Receptor EP4 Subtype
    Yoko Sakuma, Kiyoshi Tanaka, Michio Suda, Yasato Komatsu, Akihiro Yasoda, Masako Miura, Ami Ozasa, Shuh Narumiya, Yukihiko Sugimoto, Atsushi Ichikawa, Fumitaka Ushikubi, Kazuwa Nakao
  • Host Response and Inflammation
    Toll-Like Receptor 4-Deficient Mice Have Reduced Bone Destruction following Mixed Anaerobic Infection
    Linda Hou, Hajime Sasaki, Philip Stashenko
  • MOLECULAR AND CELLULAR PATHOGENESIS
    Effect of MALP-2, a Lipopeptide fromMycoplasma fermentans, on Bone Resorption In Vitro
    Grazyna Piec, Jelena Mirkovitch, Silvia Palacio, Peter F. Mühlradt, Rolf Felix

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