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Infection and Immunity
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Borrelia burgdorferi

  • Microbial Immunity and Vaccines
    Identification of Surface Epitopes Associated with Protection against Highly Immune-Evasive VlsE-Expressing Lyme Disease Spirochetes

    The tick-borne pathogen Borrelia burgdorferi is responsible for approximately 300,000 Lyme disease (LD) cases per year in the United States. Recent increases in the number of LD cases, in addition to the spread of the tick vector and a lack of a vaccine, highlight an urgent need for designing and developing an efficacious LD vaccine.

    Maliha Batool, Salvador Eugenio C. Caoili, Lawrence J. Dangott, Ekaterina Gerasimov, Yurij Ionov, Helen Piontkivska, Alex Zelikovsky, Suryakant D. Waghela, Artem S. Rogovskyy
  • Bacterial Infections | Spotlight
    Borrelia Host Adaptation Protein (BadP) Is Required for the Colonization of a Mammalian Host by the Agent of Lyme Disease
    Trever C. Smith, Sarah M. Helm, Yue Chen, Ying-Han Lin, S. L. Rajasekhar Karna, J. Seshu
  • Microbial Immunity and Vaccines
    MyD88 Signaling in T Cells Is Critical for Effector CD4 T Cell Differentiation following a Transitional T Follicular Helper Cell Stage
    Rajakumar Mandraju, Aakanksha Jain, Yajing Gao, Zhiming Ouyang, Michael V. Norgard, Chandrashekhar Pasare
  • Bacterial Infections
    Characterization of Stress and Innate Immunity Resistance of Wild-Type and Δp66 Borrelia burgdorferi
    Michael W. Curtis, Beth L. Hahn, Kai Zhang, Chunhao Li, Richard T. Robinson, Jenifer Coburn
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis
    Tess L. Killpack, Maria Ballesteros, Stephen C. Bunnell, Alice Bedugnis, Lester Kobzik, Linden T. Hu, Tanja Petnicki-Ocwieja
  • Bacterial Infections
    Spermine and Spermidine Alter Gene Expression and Antigenic Profile of Borrelia burgdorferi
    Ying-Han Lin, Jesus A. Romo, Trever C. Smith, Ann N. Reyes, S. L. Rajasekhar Karna, Christine L. Miller, Tricia A. Van Laar, Raghunandan Yendapally, James P. Chambers, J. Seshu
  • Molecular Pathogenesis
    Outer Membrane Proteins BB0405 and BB0406 Are Immunogenic, but Only BB0405 Is Required for Borrelia burgdorferi Infection
    Binu Shrestha, Melisha R. Kenedy, Darrin R. Akins
  • Open Access
    Bacterial Infections
    The Lyme Disease Pathogen Borrelia burgdorferi Infects Murine Bone and Induces Trabecular Bone Loss
    Tian Tian Tang, Lucia Zhang, Anil Bansal, Marc Grynpas, Tara J. Moriarty
  • Host Response and Inflammation
    Antibody Response to Lyme Disease Spirochetes in the Context of VlsE-Mediated Immune Evasion
    Artem S. Rogovskyy, David C. Gillis, Yurij Ionov, Ekaterina Gerasimov, Alex Zelikovsky
  • Molecular Pathogenesis
    Borrelia burgdorferi CheY2 Is Dispensable for Chemotaxis or Motility but Crucial for the Infectious Life Cycle of the Spirochete
    Hui Xu, Syed Sultan, Aaron Yerke, Ki Hwan Moon, R. Mark Wooten, M. A. Motaleb

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