Brucella abortus
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsInteraction of Brucella abortus with Osteoclasts: a Step toward Understanding Osteoarticular Brucellosis and Vaccine SafetyOsteoarticular disease is a frequent complication of human brucellosis. Vaccination remains a critical component of brucellosis control, but there are currently no vaccines for use in humans, and no in vitro models for assessing the safety of candidate vaccines in reference to the development of bone lesions currently exist. While the effect of Brucella infection on osteoblasts has been extensively evaluated, little is...
Host Response and InflammationNeutrophils Dampen Adaptive Immunity in BrucellosisBrucella organisms are intracellular stealth pathogens of animals and humans. The bacteria overcome the assault of innate immunity at early stages of an infection.
Host Response and InflammationDepletion of Complement Enhances the Clearance of Brucella abortus in MiceBrucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement.
- Host Response and InflammationImmunoproteasome Subunits Are Required for CD8+ T Cell Function and Host Resistance to Brucella abortus Infection in Mice
- Host Response and InflammationNatural Antibody Contributes to Host Defense against an Attenuated Brucella abortus virB Mutant