Brucella melitensis
Molecular PathogenesisThe Twin-Arginine Translocation System Is Important for Stress Resistance and Virulence of Brucella melitensisBrucella, the causative agent of brucellosis, is a stealthy intracellular pathogen that is highly pathogenic to a range of mammals, including humans. The twin-arginine translocation (Tat) pathway transports folded proteins across the cytoplasmic membrane and has been implicated in virulence in many bacterial pathogens. However, the roles of the Tat system and related substrates in Brucella remain unclear. We report...
Microbial Immunity and Vaccines | SpotlightIntratracheal Inoculation with Brucella melitensis in the Pregnant Guinea Pig Is an Improved Model for Reproductive Pathogenesis and Vaccine StudiesReproductive failure is the hallmark of brucellosis in animals. An uncommon but important complication in pregnant women who become acutely infected with Brucella melitensis is spontaneous pregnancy loss or vertical transmission to the fetus. Unfortunately, the mechanism behind reproductive failure is still obscure, partially due to the lack of a proper study model....
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsBrucella Peptide Cross-Reactive Major Histocompatibility Complex Class I Presentation Activates SIINFEKL-Specific T Cell Receptor-Expressing T Cells
- Microbial Immunity and VaccinesDiscordant Brucella melitensis Antigens Yield Cognate CD8+ T Cells In Vivo
- Microbial Immunity and VaccinesAerosol Infection of BALB/c Mice with Brucella melitensis and Brucella abortus and Protective Efficacy against Aerosol Challenge