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Brucella neotomae

  • A Chemical Genetics Screen Reveals Influence of p38 Mitogen-Activated Protein Kinase and Autophagy on Phagosome Development and Intracellular Replication of <span class="named-content genus-species" id="named-content-1">Brucella neotomae</span> in Macrophages
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    A Chemical Genetics Screen Reveals Influence of p38 Mitogen-Activated Protein Kinase and Autophagy on Phagosome Development and Intracellular Replication of Brucella neotomae in Macrophages

    Brucella is an intracellular bacterial pathogen that causes chronic systemic infection in domesticated livestock and poses a zoonotic infectious risk to humans. The virulence of Brucella is critically dependent on its ability to replicate and survive within host macrophages. Brucella modulates host physiological pathways and cell biology in order to establish a productive intracellular replicative niche....

    Yoon-Suk Kang, James E. Kirby
  • <em>Brucella neotomae</em> Recapitulates Attributes of Zoonotic Human Disease in a Murine Infection Model
    Bacterial Infections
    Brucella neotomae Recapitulates Attributes of Zoonotic Human Disease in a Murine Infection Model

    Members of the genus Brucella are Gram-negative pathogens that cause chronic systemic infection in farm animals and zoonotic infection in humans. Study of the genus Brucella has been hindered by the need for biosafety level 3 select agent containment.

    Yoon-Suk Kang, Daniel A. Brown, James E. Kirby
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