calprotectin
Bacterial InfectionsDisruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional ImmunityTo control infection, mammals actively withhold essential nutrients, including the transition metal manganese, by a process termed nutritional immunity. A critical component of this host response is the manganese-chelating protein calprotectin. While many bacterial mechanisms for overcoming nutritional immunity have been identified, the intersection between metal starvation and other essential inorganic nutrients has not been...
Molecular PathogenesisSynergy between Nutritional Immunity and Independent Host Defenses Contributes to the Importance of the MntABC Manganese Transporter during Staphylococcus aureus InfectionDuring infection, the host utilizes a diverse array of processes to combat invaders, including the restriction of availability of essential nutrients such as manganese. Similarly to many other pathogens, Staphylococcus aureus possesses two manganese importers, MntH and MntABC.
- Fungal and Parasitic Infections | SpotlightRole of Calprotectin in Withholding Zinc and Copper from Candida albicans