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calprotectin

  • Disruption of Phosphate Homeostasis Sensitizes <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> to Nutritional Immunity
    Bacterial Infections
    Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity

    To control infection, mammals actively withhold essential nutrients, including the transition metal manganese, by a process termed nutritional immunity. A critical component of this host response is the manganese-chelating protein calprotectin. While many bacterial mechanisms for overcoming nutritional immunity have been identified, the intersection between metal starvation and other essential inorganic nutrients has not been...

    Jessica L. Kelliher, Erin B. Brazel, Jana N. Radin, Eliot S. Joya, Paola K. Párraga Solórzano, Stephanie L. Neville, Christopher A. McDevitt, Thomas E. Kehl-Fie
  • Synergy between Nutritional Immunity and Independent Host Defenses Contributes to the Importance of the MntABC Manganese Transporter during <em>Staphylococcus aureus</em> Infection
    Molecular Pathogenesis
    Synergy between Nutritional Immunity and Independent Host Defenses Contributes to the Importance of the MntABC Manganese Transporter during Staphylococcus aureus Infection

    During infection, the host utilizes a diverse array of processes to combat invaders, including the restriction of availability of essential nutrients such as manganese. Similarly to many other pathogens, Staphylococcus aureus possesses two manganese importers, MntH and MntABC.

    Jana N. Radin, Jamie Zhu, Erin B. Brazel, Christopher A. McDevitt, Thomas E. Kehl-Fie
  • Free
    Fungal and Parasitic Infections | Spotlight
    Role of Calprotectin in Withholding Zinc and Copper from Candida albicans
    Angelique N. Besold, Benjamin A. Gilston, Jana N. Radin, Christian Ramsoomair, Edward M. Culbertson, Cissy X. Li, Brendan P. Cormack, Walter J. Chazin, Thomas E. Kehl-Fie, Valeria C. Culotta
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