CD4 T cell

  • <em>Salmonella</em> Persistence and Host Immunity Are Dictated by the Anatomical Microenvironment
    Host Response and Inflammation | Spotlight
    Salmonella Persistence and Host Immunity Are Dictated by the Anatomical Microenvironment

    The intracellular bacterial pathogen Salmonella is able to evade the immune system and persist within the host. In some cases, these persistent infections are asymptomatic for long periods and represent a significant public health hazard because the hosts are potential chronic carriers, yet the mechanisms that control persistence are incompletely understood. Using a...

    Jonathan R Kurtz, Wildaliz Nieves, David L. Bauer, Kate E. Israel, Haley E. Adcox, John S. Gunn, Lisa A. Morici, James B. McLachlan
  • CD4<sup>+</sup> T Cell Regulation of Antibodies Cross-Reactive with Fungal Cell Wall-Associated Carbohydrates after <em>Pneumocystis murina</em> Infection
    Fungal and Parasitic Infections
    CD4+ T Cell Regulation of Antibodies Cross-Reactive with Fungal Cell Wall-Associated Carbohydrates after Pneumocystis murina Infection

    Pneumocystis pneumonia is a life-threatening opportunistic fungal infection observed in individuals with severe immunodeficiencies, such as AIDS. Molecules with the ability to bind β-glucan and signal at Fcγ receptors enhance defense against Pneumocystis f.

    Rekha R. Rapaka, Guixiang Dai, Mingquan Zheng, Jay K. Kolls
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