chemotaxis
Fungal and Parasitic InfectionsMorphological and Motility Features of the Stable Bleb-Driven Monopodial Form of Entamoeba and Its Importance in EncystationEntamoeba histolytica and its reptilian counterpart and encystation model Entamoeba invadens formed a polarized monopodial morphology when treated with pentoxifylline. This morphology was propelled by retrograde flow of the cell surface resulting from a cyclic sol-gel conversion of cytoplasm and a...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsThe Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in NeutrophilsPeriodontal disease is a significant health burden, causing tooth loss and poor oral and overall systemic health. Dysbiosis of the oral biofilm and a dysfunctional immune response drive chronic inflammation, causing destruction of soft tissue and alveolar bone supporting the teeth. Treponema denticola, a spirochete abundant in the plaque biofilm of patients with...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsHelicobacter pylori Uses the TlpB Receptor To Sense Sites of Gastric InjuryHelicobacter pylori is a pathogen that chronically colonizes the stomachs of approximately half of the world’s population and contributes to the development of gastric inflammation. We demonstrated previously in vivo that H. pylori uses motility to preferentially colonize injury sites in...
Host Response and InflammationDietary Polyunsaturated Fatty Acids Promote Neutrophil Accumulation in the Spleen by Altering Chemotaxis and Delaying Cell DeathNeutrophils are the most abundant circulating leukocytes in humans and are essential for the defense against invading pathogens. Like many other cells of an organism, neutrophils can be highly influenced by the diet. We have previously described that mice fed a high-fat diet rich in polyunsaturated fatty acids (HFD-P) present a higher frequency of neutrophils in bone marrow than mice fed a high-fat diet rich in saturated fatty acids (...
- Host Response and Inflammation | SpotlightAnthrax Edema Toxin Induces Maturation of Dendritic Cells and Enhances Chemotaxis towards Macrophage Inflammatory Protein 3β
- Host Response and InflammationHelicobacter pylori Chemotaxis Modulates Inflammation and Bacterium-Gastric Epithelium Interactions in Infected Mice