Chlamydia
Host Response and InflammationEarly Colonization of the Upper Genital Tract by Chlamydia muridarum Is Associated with Enhanced Inflammation Later in InfectionChlamydia trachomatis is the most commonly reported bacterial sexually transmitted infection in the United States. Modeling infection in animals can be challenging, as mice naturally clear C. trachomatis when it is deposited in the lower genital tract. However,...
Molecular PathogenesisChlamydia muridarum Induces Pathology in the Female Upper Genital Tract via Distinct MechanismsSexually transmitted infection with Chlamydia trachomatis may lead to fibrotic blockage in women’s upper genital tracts, resulting in tubal infertility. Intravaginal inoculation with C. muridarum readily induces fibrotic blockage or hydrosalpinx in mice and is used for investigating...
Bacterial InfectionsAntigen-Specific CD4+ T Cell-Derived Gamma Interferon Is Both Necessary and Sufficient for Clearing Chlamydia from the Small Intestine but Not the Large IntestineThe genital tract pathogen Chlamydia trachomatis is frequently detected in the gastrointestinal tract, but the host immunity that regulates chlamydial colonization in the gut remains unclear. In a Chlamydia muridarum-C57 mouse model, chlamydial organisms are cleared from the genital tract in ∼4 ...
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsCharacterization of the In Vitro Chlamydia pecorum Response to Gamma Interferon
- Microbial Immunity and VaccinesNonpathogenic Colonization with Chlamydia in the Gastrointestinal Tract as Oral Vaccination for Inducing Transmucosal Protection