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Clostridium perfringens

  • Deficient Skeletal Muscle Regeneration after Injury Induced by a <span class="named-content genus-species" id="named-content-1">Clostridium perfringens</span> Strain Associated with Gas Gangrene
    Host Response and Inflammation
    Deficient Skeletal Muscle Regeneration after Injury Induced by a Clostridium perfringens Strain Associated with Gas Gangrene

    Gas gangrene, or clostridial myonecrosis, is usually caused by Clostridium perfringens and may occur spontaneously in association with diabetes mellitus, peripheral vascular disease, or some malignancies but more often after contamination of a deep surgical or traumatic lesion. If not controlled, clostridial myonecrosis results in multiorgan failure, shock, and death...

    Ana Mariel Zúñiga-Pereira, Carlos Santamaría, José María Gutierrez, Alberto Alape-Girón, Marietta Flores-Díaz
  • Potential Therapeutic Effects of Mepacrine against <em>Clostridium perfringens</em> Enterotoxin in a Mouse Model of Enterotoxemia
    Bacterial Infections
    Potential Therapeutic Effects of Mepacrine against Clostridium perfringens Enterotoxin in a Mouse Model of Enterotoxemia

    Clostridium perfringens enterotoxin (CPE) is a pore-forming toxin that causes the symptoms of common bacterial food poisoning and several non-foodborne human gastrointestinal diseases, including antibiotic-associated diarrhea and sporadic diarrhea. In some cases, CPE-mediated disease can be very severe or fatal due to the involvement of enterotoxemia.

    ...
    Mauricio A. Navarro, Archana Shrestha, John C. Freedman, Juliann Beingesser, Bruce A. McClane, Francisco A. Uzal
  • NanI Sialidase Is an Important Contributor to <span class="named-content genus-species" id="named-content-1">Clostridium perfringens</span> Type F Strain F4969 Intestinal Colonization in Mice
    Bacterial Infections
    NanI Sialidase Is an Important Contributor to Clostridium perfringens Type F Strain F4969 Intestinal Colonization in Mice

    Clostridium perfringens type F (formerly enterotoxigenic C. perfringens type A) strains produce an enterotoxin (CPE) to cause acute cases of food poisoning and chronic nonfoodborne human gastrointestinal diseases (NFD), e.g., antibiotic-associated diarrhea (AAD). NFD strains also produce NanI...

    Mauricio A. Navarro, Jihong Li, Bruce A. McClane, Eleonora Morrell, Juliann Beingesser, Francisco A. Uzal
  • NanR Regulates Sporulation and Enterotoxin Production by <span class="named-content genus-species" id="named-content-1">Clostridium perfringens</span> Type F Strain F4969
    Molecular Pathogenesis
    NanR Regulates Sporulation and Enterotoxin Production by Clostridium perfringens Type F Strain F4969

    Clostridium perfringens type F strains, which produce C. perfringens enterotoxin (CPE), are a major cause of gastrointestinal infections, including the second most prevalent bacterial foodborne illness and 5 to 10% cases of antibiotic-associated diarrhea. Virulence of type F strains is primarily...

    Eric Mi, Jihong Li, Bruce A. McClane
  • Host Response and Inflammation
    Evidence that Clostridium perfringens Enterotoxin-Induced Intestinal Damage and Enterotoxemic Death in Mice Can Occur Independently of Intestinal Caspase-3 Activation
    John C. Freedman, Mauricio A. Navarro, Eleonora Morrell, Juliann Beingesser, Archana Shrestha, Bruce A. McClane, Francisco A. Uzal
  • Molecular Pathogenesis
    NanI Sialidase Can Support the Growth and Survival of Clostridium perfringens Strain F4969 in the Presence of Sialyated Host Macromolecules (Mucin) or Caco-2 Cells
    Jihong Li, Bruce A. McClane
  • Molecular Pathogenesis
    Native or Proteolytically Activated NanI Sialidase Enhances the Binding and Cytotoxic Activity of Clostridium perfringens Enterotoxin and Beta Toxin
    James R. Theoret, Jihong Li, Mauricio A. Navarro, Jorge P. Garcia, Francisco A. Uzal, Bruce A. McClane
  • Molecular Pathogenesis
    NanR Regulates nanI Sialidase Expression by Clostridium perfringens F4969, a Human Enteropathogenic Strain
    Jihong Li, Daniel R. Evans, John C. Freedman, Bruce A. McClane
  • Molecular Pathogenesis
    The Agr-Like Quorum Sensing System Is Required for Pathogenesis of Necrotic Enteritis Caused by Clostridium perfringens in Poultry
    Qiang Yu, Dion Lepp, Iman Mehdizadeh Gohari, Tao Wu, Hongzhuan Zhou, Xianhua Yin, Hai Yu, John F. Prescott, Shao-Ping Nie, Ming-Yong Xie, Joshua Gong
  • Molecular Pathogenesis
    Immunoactive Clostridial Membrane Vesicle Production Is Regulated by a Sporulation Factor
    Nozomu Obana, Ryoma Nakao, Kyoko Nagayama, Kouji Nakamura, Hidenobu Senpuku, Nobuhiko Nomura

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