Coccidioides
Fungal and Parasitic InfectionsInterleukin-8 Receptor 2 (IL-8R2)-Deficient Mice Are More Resistant to Pulmonary Coccidioidomycosis than Control MiceThe pathology of human coccidioidomycosis is granulomatous inflammation with many neutrophils surrounding ruptured spherules, but the chemotactic pathways that draw neutrophils into the infected tissues are not known. We previously showed that formalin-killed spherules (FKS) stimulate mouse macrophages to secret macrophage inflammatory protein 2 (MIP-2), which suggested that CXC ELR+ chemokines might be involved in neutrophil...
Microbial Immunity and Vaccines | SpotlightGlucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii InfectionDeveloping an effective and safe recombinant vaccine requires microbe-specific antigens combined with an adjuvant/delivery system to strengthen protective immunity. In this study, we designed and expressed a multivalent recombinant Coccidioides polypeptide antigen (rCpa1) that consists of three previously identified antigens (i.e., Ag2/Pra, Cs-Ag, and Pmp1) and five...
- Fungal and Parasitic Infections | SpotlightMyeloid Differentiation Factor 88 and Interleukin-1R1 Signaling Contribute to Resistance to Coccidioides immitis
- Fungal and Parasitic InfectionsA Genetically Engineered Live Attenuated Vaccine of Coccidioides posadasii Protects BALB/c Mice against Coccidioidomycosis
- Fungal and Parasitic Infections | SpotlightEvaluation of Two Homologous Proline-Rich Proteins of Coccidioides posadasii as Candidate Vaccines against Coccidioidomycosis
- Fungal and Parasitic InfectionsMultivalent Recombinant Protein Vaccine against Coccidioidomycosis
- Fungal and Parasitic InfectionsSpherules Derived from Coccidioides posadasii Promote Human Dendritic Cell Maturation and Activation
- Fungal and Parasitic InfectionsUrease Produced by Coccidioides posadasii Contributes to the Virulence of This Respiratory Pathogen
- Fungal and Parasitic InfectionsA Recombinant Aspartyl Protease of Coccidioides posadasii Induces Protection against Pulmonary Coccidioidomycosis in Mice