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Infection and Immunity
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Coccidioides

  • Interleukin-8 Receptor 2 (IL-8R2)-Deficient Mice Are More Resistant to Pulmonary Coccidioidomycosis than Control Mice
    Fungal and Parasitic Infections
    Interleukin-8 Receptor 2 (IL-8R2)-Deficient Mice Are More Resistant to Pulmonary Coccidioidomycosis than Control Mice

    The pathology of human coccidioidomycosis is granulomatous inflammation with many neutrophils surrounding ruptured spherules, but the chemotactic pathways that draw neutrophils into the infected tissues are not known. We previously showed that formalin-killed spherules (FKS) stimulate mouse macrophages to secret macrophage inflammatory protein 2 (MIP-2), which suggested that CXC ELR+ chemokines might be involved in neutrophil...

    Aaron F. Carlin, Suganya Viriyakosol, Sharon Okamoto, Lorraine Walls, Joshua Fierer
  • Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary <span class="named-content genus-species" id="named-content-1">Coccidioides posadasii</span> Infection
    Microbial Immunity and Vaccines | Spotlight
    Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection

    Developing an effective and safe recombinant vaccine requires microbe-specific antigens combined with an adjuvant/delivery system to strengthen protective immunity. In this study, we designed and expressed a multivalent recombinant Coccidioides polypeptide antigen (rCpa1) that consists of three previously identified antigens (i.e., Ag2/Pra, Cs-Ag, and Pmp1) and five...

    Chiung-Yu Hung, Hao Zhang, Natalia Castro-Lopez, Gary R. Ostroff, Payam Khoshlenar, Ambily Abraham, Garry T. Cole, Austin Negron, Thomas Forsthuber, Tao Peng, John N. Galgiani, Neil M. Ampel, Jieh-Juen Yu
  • Fungal and Parasitic Infections | Spotlight
    Myeloid Differentiation Factor 88 and Interleukin-1R1 Signaling Contribute to Resistance to Coccidioides immitis
    Suganya Viriyakosol, Lorraine Walls, Sharon Okamoto, Eyal Raz, David L. Williams, Joshua Fierer
  • Fungal and Parasitic Infections
    A Genetically Engineered Live Attenuated Vaccine of Coccidioides posadasii Protects BALB/c Mice against Coccidioidomycosis
    Jianmin Xue, Xia Chen, Dale Selby, Chiung-Yu Hung, Jieh-Juen Yu, Garry T. Cole
  • Fungal and Parasitic Infections | Spotlight
    Evaluation of Two Homologous Proline-Rich Proteins of Coccidioides posadasii as Candidate Vaccines against Coccidioidomycosis
    Roger A. Herr, Chiung-Yu Hung, Garry T. Cole
  • Fungal and Parasitic Infections
    Multivalent Recombinant Protein Vaccine against Coccidioidomycosis
    Eric J. Tarcha, Venkatesha Basrur, Chiung-Yu Hung, Malcolm J. Gardner, Garry T. Cole
  • Fungal and Parasitic Infections
    Spherules Derived from Coccidioides posadasii Promote Human Dendritic Cell Maturation and Activation
    Sara O. Dionne, Abigail B. Podany, Yvette W. Ruiz, Neil M. Ampel, John N. Galgiani, Douglas F. Lake
  • Fungal and Parasitic Infections
    Protein Expression Profiling of Coccidioides posadasii by Two-Dimensional Differential In-Gel Electrophoresis and Evaluation of a Newly Recognized Peroxisomal Matrix Protein as a Recombinant Vaccine Candidate
    Kris I. Orsborn, Lisa F. Shubitz, Tao Peng, Ellen M. Kellner, Marc J. Orbach, Paul A. Haynes, John N. Galgiani
  • Fungal and Parasitic Infections
    Urease Produced by Coccidioides posadasii Contributes to the Virulence of This Respiratory Pathogen
    Fariba Mirbod-Donovan, Ruth Schaller, Chiung-Yu Hung, Jianmin Xue, Utz Reichard, Garry T. Cole
  • Fungal and Parasitic Infections
    A Recombinant Aspartyl Protease of Coccidioides posadasii Induces Protection against Pulmonary Coccidioidomycosis in Mice
    Eric J. Tarcha, Venkatesha Basrur, Chiung-Yu Hung, Malcolm J. Gardner, Garry T. Cole

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