colonization
Microbial Immunity and Vaccines | SpotlightScreening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune ResponsesConjugate vaccines against Streptococcus pneumoniae have significantly reduced the incidence of diseases caused by the serotypes included in those vaccines; however, there is still a need for vaccines that confer serotype-independent protection. In the current study, we have constructed a library of conserved surface proteins from...
- Cellular Microbiology: Pathogen-Host Cell Molecular Interactions | SpotlightEnzymatic Hydrolysis of Pneumococcal Capsular Polysaccharide Renders the Bacterium Vulnerable to Host Defense
Despite a century of investigation, Streptococcus pneumoniae remains a major human pathogen, causing a number of diseases, such as pneumonia, meningitis, and otitis media. Like many encapsulated pathogens, the capsular polysaccharide (CPS) of S. pneumoniae is a critical component for colonization...
- Microbial Immunity and VaccinesTh17-Mediated Cross Protection against Pneumococcal Carriage by Vaccination with a Variable Antigen
- Microbial Immunity and VaccinesMucosal Antibodies to the C Terminus of Toxin A Prevent Colonization of Clostridium difficile