cystic fibrosis
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsAcid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary InfectionsPrevious studies have shown that sphingosine kills a variety of pathogenic bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus. Sphingosine concentrations are decreased in airway epithelial cells of cystic fibrosis (CF) mice, and this defect has been linked to the infection...
Bacterial InfectionsScnn1b-Transgenic BALB/c Mice as a Model of Pseudomonas aeruginosa Infections of the Cystic Fibrosis LungThe opportunistic pathogen Pseudomonas aeruginosa is responsible for much of the morbidity and mortality associated with cystic fibrosis (CF), a condition that predisposes patients to chronic lung infections. P. aeruginosa lung infections are difficult to treat because...
Host Response and InflammationMycobacterium abscessus Clearance by Neutrophils Is Independent of AutophagyMycobacterium abscessus, a rapidly growing nontuberculous mycobacterium, is increasingly prevalent in chronic lung disease, including cystic fibrosis, and infections are characterized by neutrophil-dominated environments. However, mechanisms of immune control are poorly understood. Azithromycin, a macrolide antibiotic with immunomodulatory effects, is used to treat...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsAchromobacter xylosoxidans Cellular Pathology Is Correlated with Activation of a Type III Secretion SystemAchromobacter xylosoxidans is increasingly recognized as a colonizer of cystic fibrosis (CF) patients, but the role that A. xylosoxidans plays in pathology remains unknown. This knowledge gap is largely due to the lack of model systems available to study the toxic potential of this bacterium....
Host-Associated Microbial CommunitiesCooperativity between Stenotrophomonas maltophilia and Pseudomonas aeruginosa during Polymicrobial Airway InfectionsStenotrophomonas maltophilia is a Gram-negative bacterium found ubiquitously in the environment that has historically been regarded as nonpathogenic. S. maltophilia is increasingly observed in patient sputa in cystic fibrosis (CF), and while existing epidemiology indicates that patients with...
- Fungal and Parasitic Infections | SpotlightThe Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsPseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsImmune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa