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Infection and Immunity
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cytokines

  • Immunologic Pathways in Protective versus Maladaptive Host Responses to Attenuated and Pathogenic Strains of <span class="named-content genus-species" id="named-content-1">Mycoplasma gallisepticum</span>
    Host Response and Inflammation
    Immunologic Pathways in Protective versus Maladaptive Host Responses to Attenuated and Pathogenic Strains of Mycoplasma gallisepticum

    Mycoplasmas are small bacterial commensals or pathogens that commonly colonize host mucosal tissues and avoid rapid clearance, in part by stimulating inflammatory, immunopathogenic responses. We previously characterized a wide array of transcriptomic perturbations in avian host tracheal mucosae infected with virulent, immunopathologic Mycoplasma gallisepticum; however...

    Jessica Beaudet, Edan R. Tulman, Katherine Pflaum, Jessica A. Canter, Lawrence K. Silbart, Steven J. Geary
  • Viable <span class="named-content genus-species" id="named-content-1">Coxiella burnetii</span> Induces Differential Cytokine Responses in Chronic Q Fever Patients Compared to Heat-Killed <span class="named-content genus-species" id="named-content-2">Coxiella burnetii</span>
    Bacterial Infections
    Viable Coxiella burnetii Induces Differential Cytokine Responses in Chronic Q Fever Patients Compared to Heat-Killed Coxiella burnetii

    Cytokine responses of chronic Q fever patients to the intracellular bacterium Coxiella burnetii have mostly been studied using ex vivo stimulation of immune cells with heat-killed C. burnetii due to the extensive measures needed to work with viable biosafety level 3 agents. Whether research...

    Anne F. M. Jansen, Annemieke Dinkla, Hendrik-Jan Roest, Chantal P. Bleeker-Rovers, Teske Schoffelen, Leo A. B. Joosten, Peter C. Wever, Marcel van Deuren, Ad P. Koets
  • Host Response and Inflammation
    Interleukin-17A Exacerbates Disease Severity in BALB/c Mice Susceptible to Lung Infection with Mycoplasma pulmonis

    Mycoplasmas are atypical bacteria that disrupt the immune response to promote respiratory tract infections and secondary complications. However, not every immunologic response that protects or damages the host during mycoplasma infection is known.

    Maximillion T. Mize, Xiangle L. Sun, Jerry W. Simecka
  • Bacterial Infections | Spotlight
    Characterization of a Two-Component System Transcriptional Regulator, LtdR, That Impacts Group B Streptococcal Colonization and Disease
    Liwen Deng, Rong Mu, Thomas A. Weston, Brady L. Spencer, Roxanne P. Liles, Kelly S. Doran
  • Fungal and Parasitic Infections
    Cytokines, Antibodies, and Histopathological Profiles during Giardia Infection and Variant-Specific Surface Protein-Based Vaccination
    Marianela C. Serradell, Pablo R. Gargantini, Alicia Saura, Sergio R. Oms, Lucía L. Rupil, Luciana Berod, Tim Sparwasser, Hugo D. Luján
  • Host Response and Inflammation
    Human Interleukin-32γ Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice
    Rodrigo Saar Gomes, Muriel Vilela Teodoro Silva, Jéssica Cristina dos Santos, Christine van Linge, Juliana Machado Reis, Mauro Martins Teixeira, Sebastião Alves Pinto, Miriam Leandro Dorta, Xiyuan Bai, Edward D. Chan, Charles A. Dinarello, Milton Adriano Pelli Oliveira, Leo A. B. Joosten, Fátima Ribeiro-Dias
  • Fungal and Parasitic Infections
    Differential In Vitro Cytokine Induction by the Species of Cryptococcus gattii Complex
    Patricia F. Herkert, Jessica C. dos Santos, Ferry Hagen, Fatima Ribeiro-Dias, Flávio Queiroz-Telles, Mihai G. Netea, Jacques F. Meis, Leo A. B. Joosten
  • Fungal and Parasitic Infections
    Genetic Polymorphisms in Cytokine Genes in Colombian Patients with Ocular Toxoplasmosis
    C. A. Naranjo-Galvis, A. de-la-Torre, L. E. Mantilla-Muriel, L. Beltrán-Angarita, X. Elcoroaristizabal-Martín, R. McLeod, N. Alliey-Rodriguez, I. J. Begeman, C. López de Mesa, J. E. Gómez-Marín, J. C. Sepúlveda-Arias
  • Host Response and Inflammation
    Aspergillus fumigatus Preexposure Worsens Pathology and Improves Control of Mycobacterium abscessus Pulmonary Infection in Mice
    Leticia Monin, Shail Mehta, Waleed Elsegeiny, Radha Gopal, Jeremy P. McAleer, Tim D. Oury, Jay Kolls, Shabaana A. Khader
  • Open Access
    Microbial Immunity and Vaccines
    Plasmodium falciparum PfEMP1 Modulates Monocyte/Macrophage Transcription Factor Activation and Cytokine and Chemokine Responses
    Natália Guimarães Sampaio, Emily Marie Eriksson, Louis Schofield

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