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DBLβ

  • Microbial Immunity and Vaccines
    Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLβ Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea

    Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration to the cerebral microvasculature via binding of DBLβ domains to intercellular adhesion molecule 1 (ICAM1) and is associated with severe cerebral malaria. In a cohort of 187 young children from Papua New Guinea (PNG), we examined baseline levels of antibody to the ICAM1-...

    Sofonias K. Tessema, Digjaya Utama, Olga Chesnokov, Anthony N. Hodder, Clara S. Lin, G. L. Abby Harrison, Jakob S. Jespersen, Bent Petersen, Livingstone Tavul, Peter Siba, Dominic Kwiatkowski, Thomas Lavstsen, Diana S. Hansen, Andrew V. Oleinikov, Ivo Mueller, Alyssa E. Barry
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