dental caries
Bacterial InfectionsContribution of Severe Dental Caries Induced by Streptococcus mutans to the Pathogenicity of Infective EndocarditisStreptococcus mutans, a major pathogen of dental caries, is regarded as a causative agent of infective endocarditis (IE), which mainly occurs in patients with underlying heart disease. However, it remains unknown whether severe dental caries that extend to pulp space represent a possible route of infection. In the present study, we evaluated the virulence of...
Microbial Immunity and VaccinesThe Combinations Chitosan-Pam3CSK4 and Chitosan-Monophosphoryl Lipid A: Promising Immune-Enhancing Adjuvants for Anticaries Vaccine PAcWe previously demonstrated that recombinant protein PAc could be administered as an anticaries vaccine. However, the relatively weak immunogenicity of PAc limits its application. In the present study, we investigated the effect of two adjuvant combinations of chitosan plus Pam3CSK4 (chitosan-Pam3CSK4) and of chitosan plus monophosphoryl lipid A (chitosan-MPL) in the immune responses to the PAc...
- Microbial Immunity and VaccinesImmunological and Protective Effects of Diepitopic Subunit Dental Caries Vaccines
- Host Response and InflammationS100 and Cytokine Expression in Caries