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Infection and Immunity
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diagnostics

  • Open Access
    Lipopolysaccharides from Different <em>Burkholderia</em> Species with Different Lipid A Structures Induce Toll-Like Receptor 4 Activation and React with Melioidosis Patient Sera
    Host Response and Inflammation
    Lipopolysaccharides from Different Burkholderia Species with Different Lipid A Structures Induce Toll-Like Receptor 4 Activation and React with Melioidosis Patient Sera

    Lipopolysaccharides (LPSs) of Gram-negative bacteria comprise lipid A, core, and O-polysaccharide (OPS) components. Studies have demonstrated that LPSs isolated from the pathogenic species Burkholderia pseudomallei and Burkholderia mallei and from less-pathogenic species, such as...

    Sineenart Sengyee, Sung Hwan Yoon, T. Eoin West, Robert K. Ernst, Narisara Chantratita
  • Tracking Anti-<em>Staphylococcus aureus</em> Antibodies Produced <em>In Vivo</em> and <em>Ex Vivo</em> during Foot Salvage Therapy for Diabetic Foot Infections Reveals Prognostic Insights and Evidence of Diversified Humoral Immunity
    Bacterial Infections
    Tracking Anti-Staphylococcus aureus Antibodies Produced In Vivo and Ex Vivo during Foot Salvage Therapy for Diabetic Foot Infections Reveals Prognostic Insights and Evidence of Diversified Humoral Immunity

    Management of foot salvage therapy (FST) for diabetic foot infections (DFI) is challenging due to the absence of reliable diagnostics to identify the etiologic agent and prognostics to justify aggressive treatments. As Staphylococcus aureus is the most common pathogen associated with DFI, we aimed to develop a multiplex immunoassay of IgG in serum and medium enriched...

    Irvin Oh, Gowrishankar Muthukrishnan, Mark J. Ninomiya, James D. Brodell, Benjamin L. Smith, Charles C. Lee, Steven R. Gill, Christopher A. Beck, Edward M. Schwarz, John L. Daiss
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