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Enterococcus

  • Genome-Wide Mutagenesis Identifies Factors Involved in <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Vaginal Adherence and Persistence
    Molecular Pathogenesis | Spotlight
    Genome-Wide Mutagenesis Identifies Factors Involved in Enterococcus faecalis Vaginal Adherence and Persistence

    Enterococcus faecalis is a Gram-positive commensal bacterium native to the gastrointestinal tract and an opportunistic pathogen of increasing clinical concern. E. faecalis also colonizes the female reproductive tract, and reports suggest vaginal colonization increases following antibiotic treatment...

    Norhan Alhajjar, Anushila Chatterjee, Brady L. Spencer, Lindsey R. Burcham, Julia L. E. Willett, Gary M. Dunny, Breck A. Duerkop, Kelly S. Doran
  • <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Gluconate Phosphotransferase System Accelerates Experimental Colitis and Bacterial Killing by Macrophages
    Host Response and Inflammation
    Enterococcus faecalis Gluconate Phosphotransferase System Accelerates Experimental Colitis and Bacterial Killing by Macrophages

    Enterococcus faecalis strains are resident intestinal bacteria associated with invasive infections, inflammatory bowel diseases, and colon cancer. Although factors promoting E. faecalis colonization of intestines are not fully known, one implicated pathway is a phosphotransferase system (PTS) in...

    Ting-Jia Fan, Laura Goeser, Arash Naziripour, Matthew R. Redinbo, Jonathan J. Hansen
  • Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci
    Host-Associated Microbial Communities | Spotlight
    Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci

    Enterococcus faecalis is a human intestinal pathobiont with intrinsic and acquired resistance to many antibiotics, including vancomycin. Nature provides a diverse and virtually untapped repertoire of bacterial viruses, or bacteriophages (phages), that could be harnessed to combat multidrug-resistant enterococcal infections.

    Anushila Chatterjee, Cydney N. Johnson, Phat Luong, Karthik Hullahalli, Sara W. McBride, Alyxandria M. Schubert, Kelli L. Palmer, Paul E. Carlson, Breck A. Duerkop
  • Sortase-Dependent Proteins Promote Gastrointestinal Colonization by Enterococci
    Host-Associated Microbial Communities | Spotlight
    Sortase-Dependent Proteins Promote Gastrointestinal Colonization by Enterococci

    The human gastrointestinal tract (GIT) is inhabited by a dense microbial community of symbionts. Enterococci are among the earliest members of this community and remain core members of the GIT microbiota throughout life.

    Leou Ismael Banla, Adam M. Pickrum, Michael Hayward, Christopher J. Kristich, Nita H. Salzman
  • Ceftriaxone Administration Disrupts Intestinal Homeostasis, Mediating Noninflammatory Proliferation and Dissemination of Commensal Enterococci
    Host-Associated Microbial Communities
    Ceftriaxone Administration Disrupts Intestinal Homeostasis, Mediating Noninflammatory Proliferation and Dissemination of Commensal Enterococci

    Enterococci are Gram-positive commensals of the mammalian intestinal tract and harbor intrinsic resistance to broad-spectrum cephalosporins. Disruption of colonization resistance in humans by antibiotics allows enterococci to proliferate in the gut and cause disseminated infections.

    Rajrupa Chakraborty, Vy Lam, Sushma Kommineni, Jeremiah Stromich, Michael Hayward, Christopher J. Kristich, Nita H. Salzman
  • Molecular Pathogenesis
    Modulators of Enterococcus faecalis Cell Envelope Integrity and Antimicrobial Resistance Influence Stable Colonization of the Mammalian Gastrointestinal Tract
    Ismael L. Banla, Sushma Kommineni, Michael Hayward, Marinelle Rodrigues, Kelli L. Palmer, Nita H. Salzman, Christopher J. Kristich
  • Bacterial Infections
    The Electron Transport Chain Sensitizes Staphylococcus aureus and Enterococcus faecalis to the Oxidative Burst
    Kimberley L. Painter, Alex Hall, Kam Pou Ha, Andrew M. Edwards
  • Molecular Pathogenesis
    Association of Metal Homeostasis and (p)ppGpp Regulation in the Pathophysiology of Enterococcus faecalis
    C. Colomer-Winter, A. O. Gaca, J. A. Lemos
  • Bacterial Infections
    The Pathogenic Potential of Proteus mirabilis Is Enhanced by Other Uropathogens during Polymicrobial Urinary Tract Infection
    Chelsie E. Armbruster, Sara N. Smith, Alexandra O. Johnson, Valerie DeOrnellas, Kathryn A. Eaton, Alejandra Yep, Lona Mody, Weisheng Wu, Harry L. T. Mobley
  • Microbial Immunity and Vaccines
    Evidence of Immunostimulating Lipoprotein Existing in the Natural Lipoteichoic Acid Fraction
    Masahito Hashimoto, Maiko Furuyashiki, Ryoko Kaseya, Yuka Fukada, Mai Akimaru, Kazue Aoyama, Toshiomi Okuno, Toshihide Tamura, Teruo Kirikae, Fumiko Kirikae, Nobutaka Eiraku, Hirofumi Morioka, Yukari Fujimoto, Koichi Fukase, Katsuhiro Takashige, Yoichiro Moriya, Shoichi Kusumoto, Yasuo Suda
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