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Infection and Immunity
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eosinophils

  • Aging Dampens the Intestinal Innate Immune Response during Severe <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> Infection and Is Associated with Altered Cytokine Levels and Granulocyte Mobilization
    Host Response and Inflammation | Spotlight
    Aging Dampens the Intestinal Innate Immune Response during Severe Clostridioides difficile Infection and Is Associated with Altered Cytokine Levels and Granulocyte Mobilization

    Clostridioides (formerly Clostridium) difficile is the most common cause of hospital-acquired infection, and advanced age is a risk factor for C. difficile infection. Disruption of the intestinal microbiota and immune responses contribute to host susceptibility and severity of C...

    Lisa Abernathy-Close, Michael G. Dieterle, Kimberly C. Vendrov, Ingrid L. Bergin, Krishna Rao, Vincent B. Young
  • Eosinophils Affect Antibody Isotype Switching and May Partially Contribute to Early Vaccine-Induced Immunity against <span class="named-content genus-species" id="named-content-1">Coxiella burnetii</span>
    Microbial Immunity and Vaccines
    Eosinophils Affect Antibody Isotype Switching and May Partially Contribute to Early Vaccine-Induced Immunity against Coxiella burnetii

    Coxiella burnetii is an obligate intracellular Gram-negative bacterium which causes human Q fever. An acidified citrate cysteine medium (ACCM-2) has been developed which mimics the intracellular replicative niche of C. burnetii and allows axenic growth of the bacteria.

    Lindsey Ledbetter, Rama Cherla, Catherine Chambers, Yan Zhang, Guoquan Zhang
  • Eosinophils and Macrophages within the Th2-Induced Granuloma: Balancing Killing and Healing in a Tight Space
    Minireview
    Eosinophils and Macrophages within the Th2-Induced Granuloma: Balancing Killing and Healing in a Tight Space

    Granuloma formation is a key host immune response generated to confine invading pathogens and limit extensive host damage. It consists of an accumulation of host immune cells around a pathogen. This host response has been extensively studied in the context of inflammatory diseases. However, there is much less known about Th2-type granulomas generated in response to parasitic worms.

    Anupama Ariyaratne, Constance A. M. Finney
  • Host Response and Inflammation
    Heightened Systemic Levels of Neutrophil and Eosinophil Granular Proteins in Pulmonary Tuberculosis and Reversal following Treatment
    Kadar Moideen, Nathella Pavan Kumar, Dina Nair, Vaithilingam V. Banurekha, Ramalingam Bethunaickan, Subash Babu
  • Host Response and Inflammation
    Mouse Eosinophils Possess Potent Antibacterial Properties In Vivo
    Stefanie N. Linch, Ann M. Kelly, Erin T. Danielson, Ralph Pero, James J. Lee, Jeffrey A. Gold
  • Host Response and Inflammation
    Vacuolating Cytotoxin in Helicobacter pylori Water-Soluble Proteins Upregulates Chemokine Expression in Human Eosinophils via Ca2+ Influx, Mitochondrial Reactive Oxygen Intermediates, and NF-κB Activation
    Jung Mogg Kim, Joo Sung Kim, Jin Young Lee, Yeong-Jeon Kim, Ho-Joo Youn, In Young Kim, Young Joon Chee, Yu-Kyoung Oh, Nayoung Kim, Hyun Chae Jung, In Sung Song
  • Fungal and Parasitic Infections
    Peritoneal Lavage Cells of Indonesian Thin-Tail Sheep Mediate Antibody-Dependent Superoxide Radical Cytotoxicity In Vitro against Newly Excysted Juvenile Fasciola gigantica but Not Juvenile Fasciola hepatica
    David Piedrafita, Endah Estuningsih, Jill Pleasance, Rhoda Prowse, Herman W. Raadsma, Els N. T. Meeusen, Terry W. Spithill
  • Host Response and Inflammation
    Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy
    Heloisa D'Ávila, Patrícia E. Almeida, Natália R. Roque, Hugo C. Castro-Faria-Neto, Patrícia T. Bozza
  • Fungal and Parasitic Infections
    Role of Eosinophils and Neutrophils in Innate and Adaptive Protective Immunity to Larval Strongyloides stercoralis in Mice
    Ann Marie Galioto, Jessica A. Hess, Thomas J. Nolan, Gerhard A. Schad, James J. Lee, David Abraham
  • Fungal and Parasitic Infections
    Lack of Eosinophil Peroxidase or Major Basic Protein Impairs Defense against Murine Filarial Infection
    Sabine Specht, Michael Saeftel, Manuela Arndt, Elmar Endl, Bettina Dubben, Nancy A. Lee, James J. Lee, Achim Hoerauf

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