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Infection and Immunity
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ETEC

  • Open Access
    Evaluation of the Immunogenicity and Protective Efficacy of an Enterotoxigenic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> CFA/I Adhesin–Heat-Labile Toxin Chimera
    Microbial Immunity and Vaccines
    Evaluation of the Immunogenicity and Protective Efficacy of an Enterotoxigenic Escherichia coli CFA/I Adhesin–Heat-Labile Toxin Chimera

    Recent efforts to develop an enterotoxigenic Escherichia coli (ETEC) vaccine have focused on the antigenically conserved tip adhesins of colonization factors. We showed previously that intranasal immunization with dsc19CfaE, a soluble variant of the in cis donor strand-complemented tip adhesin of a colonization factor of the class 5 family (CFA/I)...

    Aisling O'Dowd, Milton Maciel, Steven T. Poole, Michael G. Jobling, Julianne E. Rollenhagen, Colleen M. Woods, Stephanie A. Sincock, Annette L. McVeigh, Michael J. Gregory, Ryan C. Maves, Michael G. Prouty, Randall K. Holmes, Stephen J. Savarino
  • Open Access
    Cross-Reactivity, Epitope Mapping, and Potency of Monoclonal Antibodies to Class 5 Fimbrial Tip Adhesins of Enterotoxigenic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Microbial Immunity and Vaccines
    Cross-Reactivity, Epitope Mapping, and Potency of Monoclonal Antibodies to Class 5 Fimbrial Tip Adhesins of Enterotoxigenic Escherichia coli

    Enterotoxigenic Escherichia coli (ETEC) is a leading diarrheagenic bacterial pathogen among travelers and children in resource-limited regions. Adherence to host intestinal cells mediated by ETEC fimbriae is believed to be a critical first step in ETEC pathogenesis. These fimbriae are categorized into related classes based on sequence similarity, with members of the...

    Yang Liu, Sakina Shahabudin, Sami Farid, Lanfong H. Lee, Annette L. McVeigh, Milton Maciel, Steven T. Poole, Matthew Broadman, Michael G. Prouty, Stephen J. Savarino
  • Mechanical Stimuli Affect <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model
    Molecular Pathogenesis
    Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model

    Modeling host-pathogen interactions with human intestinal epithelia using enteroid monolayers on permeable supports (such as Transwells) represents an alternative to animal studies or use of colon cancer-derived cell lines. However, the static monolayer model does not expose epithelial cells to mechanical forces normally present in the intestine, including luminal flow and serosal blood flow (shear force) or peristaltic forces.

    ...
    Laxmi Sunuwar, Jianyi Yin, Magdalena Kasendra, Katia Karalis, James Kaper, James Fleckenstein, Mark Donowitz
  • Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Microbial Immunity and Vaccines
    Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli

    Enterotoxigenic Escherichia coli (ETEC) is a major cause of infectious diarrhea in children, travelers, and deployed military personnel. As such, development of a vaccine would be advantageous for public health. One strategy is to use subunits of colonization factors combined with antigen/adjuvant toxoids as an ETEC vaccine.

    Milton Maciel, David Bauer, Robin L. Baudier, Jacob Bitoun, John D. Clements, Steven T. Poole, Mark A. Smith, Robert W. Kaminski, Stephen J. Savarino, Elizabeth B. Norton
  • Immunizations with Enterotoxigenic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Heat-Stable Toxin Conjugates Engender Toxin-Neutralizing Antibodies in Mice That Also Cross-React with Guanylin and Uroguanylin
    Microbial Immunity and Vaccines
    Immunizations with Enterotoxigenic Escherichia coli Heat-Stable Toxin Conjugates Engender Toxin-Neutralizing Antibodies in Mice That Also Cross-React with Guanylin and Uroguanylin

    Infection with enterotoxigenic Escherichia coli (ETEC) is a common cause of childhood diarrhea in low- and middle-income countries, as well as of diarrhea among travelers to these countries. In children, ETEC strains secreting the heat-stable toxin (ST) are the most pathogenic, and there are ongoing efforts to develop vaccines that target ST.

    Yuleima Diaz, Morten L. Govasli, Ephrem Debebe Zegeye, Halvor Sommerfelt, Hans Steinsland, Pål Puntervoll
  • Open Access
    Microbial Immunity and Vaccines | Spotlight
    Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection

    Enterotoxigenic Escherichia coli (ETEC) causes diarrheal illness in infants in the developing world and travelers to countries where the disease is endemic, including military personnel. ETEC infection of the host involves colonization of the small intestinal epithelium and toxin secretion, leading to watery diarrhea.

    Serena Giuntini, Matteo Stoppato, Maja Sedic, Monir Ejemel, Jessica R. Pondish, Danielle Wisheart, Zachary A. Schiller, William D. Thomas, Eileen M. Barry, Lisa A. Cavacini, Mark S. Klempner, Yang Wang
  • Open Access
    Bacterial Infections | Spotlight
    Critical Role of Zinc in a New Murine Model of Enterotoxigenic Escherichia coli Diarrhea
    D. T. Bolick, P. H. Q. S. Medeiros, S. E. Ledwaba, A. A. M. Lima, J. P. Nataro, E. M. Barry, R. L. Guerrant
  • Microbial Immunity and Vaccines
    Enterotoxigenic Escherichia coli Adhesin-Toxoid Multiepitope Fusion Antigen CFA/I/II/IV-3xSTaN12S-mnLTG192G/L211A-Derived Antibodies Inhibit Adherence of Seven Adhesins, Neutralize Enterotoxicity of LT and STa Toxins, and Protect Piglets against Diarrhea
    Rahul Nandre, Xiaosai Ruan, Ti Lu, Qiangde Duan, David Sack, Weiping Zhang
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