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flagellar motility

  • Distinct Contributions of CD18 Integrins for Binding and Phagocytic Internalization of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span>
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Distinct Contributions of CD18 Integrins for Binding and Phagocytic Internalization of Pseudomonas aeruginosa

    Phagocytosis is the key mechanism for host control of Pseudomonas aeruginosa, a motile Gram-negative, opportunistic bacterial pathogen which frequently undergoes adaptation and selection for traits that are advantageous for survival. One such clinically relevant adaptation is the loss of bacterial motility, observed within chronic infections, that is associated with...

    Sally Demirdjian, Daniel Hopkins, Nadia Cumbal, Craig T. Lefort, Brent Berwin
  • Open Access
    Cross Talk between MarR-Like Transcription Factors Coordinates the Regulation of Motility in Uropathogenic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Molecular Pathogenesis
    Cross Talk between MarR-Like Transcription Factors Coordinates the Regulation of Motility in Uropathogenic Escherichia coli

    The MarR-like protein PapX represses the transcription of the flagellar master regulator genes flhDC in uropathogenic Escherichia coli (UPEC), the primary cause of uncomplicated urinary tract infections (UTIs). PapX is encoded by the pap operon, which also encodes the adherence factors termed P fimbriae.

    Courtney L. Luterbach, Harry L. T. Mobley
  • Open Access
    Molecular Pathogenesis
    Methylthioadenosine Suppresses Salmonella Virulence

    In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously, we showed a transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) concentration in serum during systemic Salmonella enterica serovar Typhimurium infection.

    Jeffrey S. Bourgeois, Daoguo Zhou, Teresa L. M. Thurston, James J. Gilchrist, Dennis C. Ko
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Phosphatidylinositol-(3,4,5)-Trisphosphate Induces Phagocytosis of Nonmotile Pseudomonas aeruginosa

    Pathogenic bacteria that establish chronic infections in immunocompromised patients frequently undergo adaptation or selection for traits that are advantageous for their growth and survival. Clinical isolates of Pseudomonas aeruginosa, a Gram-negative, opportunistic bacterial pathogen, exhibit a temporal transition from a motile to a nonmotile phenotype through loss...

    Sally Demirdjian, Daniel Hopkins, Hector Sanchez, Michael Libre, Scott A. Gerber, Brent Berwin
  • Molecular Pathogenesis
    A Nutrient-Regulated Cyclic Diguanylate Phosphodiesterase Controls Clostridium difficile Biofilm and Toxin Production during Stationary Phase
    Erin B. Purcell, Robert W. McKee, David S. Courson, Elizabeth M. Garrett, Shonna M. McBride, Richard E. Cheney, Rita Tamayo
  • Microbial Immunity and Vaccines
    Immunity Provided by an Outer Membrane Vesicle Cholera Vaccine Is Due to O-Antigen-Specific Antibodies Inhibiting Bacterial Motility
    Zhu Wang, David W. Lazinski, Andrew Camilli
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