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Infection and Immunity
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gene expression

  • Open Access
    Diffusible Signal Factors Act through AraC-Type Transcriptional Regulators as Chemical Cues To Repress Virulence of Enteric Pathogens
    Molecular Pathogenesis
    Diffusible Signal Factors Act through AraC-Type Transcriptional Regulators as Chemical Cues To Repress Virulence of Enteric Pathogens

    Successful colonization by enteric pathogens is contingent upon effective interactions with the host and the resident microbiota. These pathogens thus respond to and integrate myriad signals to control virulence. Long-chain fatty acids repress the virulence of the important enteric pathogens Salmonella enterica and...

    Erick Maosa Bosire, Colleen R. Eade, Carl J. Schiltz, Amanda J. Reid, Jerry Troutman, Joshua S. Chappie, Craig Altier
  • The Lon-1 Protease Is Required by <span class="named-content genus-species" id="named-content-1">Borrelia burgdorferi</span> To Infect the Mammalian Host
    Molecular Pathogenesis
    The Lon-1 Protease Is Required by Borrelia burgdorferi To Infect the Mammalian Host

    Borrelia burgdorferi encodes a functional homolog of canonical Lon protease termed Lon-2. In addition, B. burgdorferi encodes a second Lon homolog called Lon-1. Recent studies suggest that Lon-1 may function differently from the prototypical Lon protease. However, the function of Lon-1 in...

    Christina Thompson, Charlotte Mason, Shidoya Parrilla, Zhiming Ouyang
  • Molecular Pathogenesis
    Small RNA teg49 Is Derived from a sarA Transcript and Regulates Virulence Genes Independent of SarA in Staphylococcus aureus
    Adhar C. Manna, Samin Kim, Liviu Cengher, Anna Corvaglia, Stefano Leo, Patrice Francois, Ambrose L. Cheung
  • Host Response and Inflammation
    Acquired Protective Immunity in Atlantic Salmon Salmo salar against the Myxozoan Kudoa thyrsites Involves Induction of MHIIβ+ CD83+ Antigen-Presenting Cells
    Laura M. Braden, Karina J. Rasmussen, Sara L. Purcell, Lauren Ellis, Amelia Mahony, Steven Cho, Shona K. Whyte, Simon R. M. Jones, Mark D. Fast
  • Bacterial Infections
    Positive- and Negative-Control Pathways by Blood Components for Intermedilysin Production in Streptococcus intermedius
    Toshifumi Tomoyasu, Takahiro Yamasaki, Shinya Chiba, Shingo Kusaka, Atsushi Tabata, Robert A. Whiley, Hideaki Nagamune
  • Host Response and Inflammation
    Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria
    Matthew A. Huggins, Holly L. Johnson, Fang Jin, Aurelie N′Songo, Lisa M. Hanson, Stephanie J. LaFrance, Noah S. Butler, John T. Harty, Aaron J. Johnson
  • Free
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions | Spotlight
    The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1
    Sixbert I. Mkumbaye, Christian W. Wang, Eric Lyimo, Jakob S. Jespersen, Alphaxard Manjurano, Jacklin Mosha, Reginald A. Kavishe, Steven B. Mwakalinga, Daniel T. R. Minja, John P. Lusingu, Thor G. Theander, Thomas Lavstsen
  • Host Response and Inflammation
    Differential Expression of Interleukin-8 by Polymorphonuclear Leukocytes of Two Closely Related Species, Ovis canadensis and Ovis aries, in Response to Mannheimia haemolytica Infection
    Caroline N. Herndon, William J. Foreyt, Subramaniam Srikumaran
  • Fungal and Parasitic Infections | Spotlight
    Impairment of Host Defense against Disseminated Candidiasis in Mice Overexpressing GATA-3
    Norihiro Haraguchi, Yukio Ishii, Yuko Morishima, Keigyou Yoh, Yosuke Matsuno, Norihiro Kikuchi, Tohru Sakamoto, Satoru Takahashi, Nobuyuki Hizawa
  • Host Response and Inflammation
    The K5 Capsule of Escherichia coli Strain Nissle 1917 Is Important in Stimulating Expression of Toll-Like Receptor 5, CD14, MyD88, and TRIF Together with the Induction of Interleukin-8 Expression via the Mitogen-Activated Protein Kinase Pathway in Epithelial Cells
    Mohamed Hafez, Kelly Hayes, Marie Goldrick, Richard K. Grencis, Ian S. Roberts

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