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Infection and Immunity
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genomics

  • The Distinct Immune-Stimulatory Capacities of <span class="named-content genus-species" id="named-content-1">Porphyromonas gingivalis</span> Strains 381 and ATCC 33277 Are Determined by the <em>fimB</em> Allele and Gingipain Activity
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    The Distinct Immune-Stimulatory Capacities of Porphyromonas gingivalis Strains 381 and ATCC 33277 Are Determined by the fimB Allele and Gingipain Activity

    The Porphyromonas gingivalis strain ATCC 33277 (33277) and 381 genomes are nearly identical. However, strain 33277 displays a significantly diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and interleukin-1β (IL-1β) production relative to 381, suggesting that there are strain-specific differences in one or more bacterial...

    Stephen R. Coats, Nutthapong Kantrong, Thao T. To, Sumita Jain, Caroline A. Genco, Jeffrey S. McLean, Richard P. Darveau
  • Genomic, Phenotypic, and Virulence Analysis of <em>Streptococcus sanguinis</em> Oral and Infective-Endocarditis Isolates
    Molecular Genomics
    Genomic, Phenotypic, and Virulence Analysis of Streptococcus sanguinis Oral and Infective-Endocarditis Isolates

    Streptococcus sanguinis, an abundant and benign inhabitant of the oral cavity, is an important etiologic agent of infective endocarditis (IE), particularly in people with predisposing cardiac valvular damage. Although commonly isolated from patients with IE, little is known about the factors that make any particular...

    Shannon P. Baker, Tara J. Nulton, Todd Kitten
  • Open Access
    Minireview
    Genome Variation and Molecular Epidemiology of Salmonella enterica Serovar Typhimurium Pathovariants

    Salmonella enterica serovar Typhimurium is one of approximately 2,500 distinct serovars of the genus Salmonella but is exceptional in its wide distribution in the environment, livestock, and wild animals. S.

    Priscilla Branchu, Matt Bawn, Robert A. Kingsley
  • Open Access
    Molecular Genomics
    Spontaneous Loss of Virulence in Natural Populations of Listeria monocytogenes
    Mylène M. Maury, Viviane Chenal-Francisque, Hélène Bracq-Dieye, Lei Han, Alexandre Leclercq, Guillaume Vales, Alexandra Moura, Edith Gouin, Mariela Scortti, Olivier Disson, José A. Vázquez-Boland, Marc Lecuit
  • Molecular Genomics
    Characterization of the Pathogenicity of Streptococcus intermedius TYG1620 Isolated from a Human Brain Abscess Based on the Complete Genome Sequence with Transcriptome Analysis and Transposon Mutagenesis in a Murine Subcutaneous Abscess Model
    Noriko Hasegawa, Tsuyoshi Sekizuka, Yutaka Sugi, Nobuhiro Kawakami, Yumiko Ogasawara, Kengo Kato, Akifumi Yamashita, Fumihiko Takeuchi, Makoto Kuroda
  • Molecular Genomics | Spotlight
    Genomic Comparison of Virulent Rickettsia rickettsii Sheila Smith and Avirulent Rickettsia rickettsii Iowa
    Damon W. Ellison, Tina R. Clark, Daniel E. Sturdevant, Kimmo Virtaneva, Stephen F. Porcella, Ted Hackstadt
  • Molecular Genomics
    Identification of a Candidate Streptococcus pneumoniae Core Genome and Regions of Diversity Correlated with Invasive Pneumococcal Disease
    Caroline Obert, Jack Sublett, Deepak Kaushal, Ernesto Hinojosa, Theresa Barton, Elaine I. Tuomanen, Carlos J. Orihuela
  • Molecular Genomics
    Search for Bacillus anthracis Potential Vaccine Candidates by a Functional Genomic-Serologic Screen
    Orit Gat, Haim Grosfeld, Naomi Ariel, Itzhak Inbar, Galia Zaide, Yehoshua Broder, Anat Zvi, Theodor Chitlaru, Zeev Altboum, Dana Stein, Sara Cohen, Avigdor Shafferman
  • Fungal and Parasitic Infections
    Functional Genomics of Innate Host Defense Molecules in Normal Human Monocytes in Response to Aspergillus fumigatus
    Karoll J. Cortez, Caron A. Lyman, Shyam Kottilil, Hee Sup Kim, Emmanuel Roilides, Jun Yang, Brandie Fullmer, Richard Lempicki, Thomas J. Walsh
  • Molecular Genomics
    Factors Characterizing Staphylococcus epidermidis Invasiveness Determined by Comparative Genomics
    Yufeng Yao, Daniel E. Sturdevant, Amer Villaruz, Lin Xu, Qian Gao, Michael Otto

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