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Haemophilus influenzae

  • Antibody Binding and Complement-Mediated Killing of Invasive <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> Isolates from Spain, Portugal, and the Netherlands
    Molecular Pathogenesis
    Antibody Binding and Complement-Mediated Killing of Invasive Haemophilus influenzae Isolates from Spain, Portugal, and the Netherlands

    Haemophilus influenzae is a Gram-negative bacterium that can be classified into typeable (types a through f) and nontypeable (NTHi) groups. This opportunistic pathogen asymptomatically colonizes the mucosal epithelium of the upper respiratory tract, from where it spreads to other neighboring regions, potentially leading to disease. Infection with NTHi can cause otitis...

    Elena Dudukina, Laura de Smit, Giel J. A. Verhagen, Arie van de Ende, José María Marimón, Paula Bajanca-Lavado, Carmen Ardanuy, Sara Marti, Marien I. de Jonge, Jeroen D. Langereis
  • Open Access
    Nasal Delivery of a Commensal <em>Pasteurellaceae</em> Species Inhibits Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> Colonization and Delays Onset of Otitis Media in Mice
    Bacterial Infections
    Nasal Delivery of a Commensal Pasteurellaceae Species Inhibits Nontypeable Haemophilus influenzae Colonization and Delays Onset of Otitis Media in Mice

    Nasopharyngeal colonization with nontypeable Haemophilus influenzae (NTHi) is a prerequisite for developing NTHi-associated infections, including otitis media. Therapies that block NTHi colonization may prevent disease development. We previously demonstrated that Haemophilus haemolyticus, a closely...

    Caitlyn M. Granland, Naomi M. Scott, Jean-Francois Lauzon-Joset, Jeroen D. Langereis, Camilla de Gier, Katrien M. J. Sutherland, Sharon L. Clark, Janessa L. Pickering, Ruth B. Thornton, Peter C. Richmond, Deborah H. Strickland, Lea-Ann S. Kirkham
  • Underlying Glycans Determine the Ability of Sialylated Lipooligosaccharide To Protect Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> from Serum IgM and Complement
    Molecular Pathogenesis
    Underlying Glycans Determine the Ability of Sialylated Lipooligosaccharide To Protect Nontypeable Haemophilus influenzae from Serum IgM and Complement

    Nontypeable Haemophilus influenzae (NTHi) efficiently colonizes the human nasopharynx asymptomatically but also causes respiratory mucosal infections, including otitis media, sinusitis, and bronchitis. The lipooligosaccharide (LOS) on the cell surface of NTHi displays complex glycans that mimic host structures, allowing it to evade immune recognition. However, LOS...

    Mary Darby Jackson, Sandy M. Wong, Brian J. Akerley
  • Open Access
    Design and Characterization of Protein E-PilA, a Candidate Fusion Antigen for Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> Vaccine
    Microbial Immunity and Vaccines | Spotlight
    Design and Characterization of Protein E-PilA, a Candidate Fusion Antigen for Nontypeable Haemophilus influenzae Vaccine

    Nontypeable Haemophilus influenzae (NTHi) is a pathogen known for being a frequent cause of acute otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. In the present study, a vaccine antigen based on the fusion of two known NTHi adhesive proteins, protein E (PE) and a pilin subunit (PilA), was developed. The...

    Normand Blais, Don Somers, Denis Faubert, Steve Labbé, Cindy Castado, Carine Ysebaert, Louis-Patrick Gagnon, Josée Champagne, Martin Gagné, Denis Martin
  • Open Access
    A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> in Mice and Chinchillas
    Microbial Immunity and Vaccines | Spotlight
    A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas

    PE-PilA is a fusion protein composed of immunologically relevant parts of protein E (PE) and the majority subunit of the type IV pilus (PilA), two major antigens of nontypeable Haemophilus influenzae (NTHi). Here we report on the preclinical evaluation of PE-PilA as a vaccine antigen. The immunogenic potential of the PE and PilA within the fusion was compared with...

    Carine Ysebaert, Philippe Denoël, Vincent Weynants, Lauren O. Bakaletz, Laura A. Novotny, Fabrice Godfroid, Philippe Hermand
  • Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable <em>Haemophilus influenzae</em> Increases Complement-Mediated Killing
    Molecular Pathogenesis
    Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable Haemophilus influenzae Increases Complement-Mediated Killing

    Nontypeable Haemophilus influenzae (NTHi) colonizes the human upper respiratory tract without causing disease symptoms, but it is also a major cause of upper and lower respiratory tract infections in children and elderly, respectively. NTHi synthesizes various molecules to decorate its lipooligosaccharide (LOS), which modulates the level of virulence.

    ...
    Jeroen D. Langereis, Eva S. van der Pasch, Marien I. de Jonge
  • Uptake of Sialic Acid by Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> Increases Complement Resistance through Decreasing IgM-Dependent Complement Activation
    Molecular Pathogenesis
    Uptake of Sialic Acid by Nontypeable Haemophilus influenzae Increases Complement Resistance through Decreasing IgM-Dependent Complement Activation

    Although nontypeable Haemophilus influenzae (NTHi) is a human-specific nasopharyngeal commensal bacterium, it also causes upper respiratory tract infections in children and lower respiratory tract infections in the elderly, resulting in frequent antibiotic use. The transition from symbiotic colonizing bacterium to opportunistic pathogen is not completely understood....

    Marjolein M. P. Oerlemans, Sam J. Moons, Jurriaan J. A. Heming, Thomas J. Boltje, Marien I. de Jonge, Jeroen D. Langereis
  • Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> Invasive Blood Isolates Are Mainly Phosphorylcholine Negative and Show Decreased Complement-Mediated Killing That Is Associated with Lower Binding of IgM and CRP in Comparison to Colonizing Isolates from the Oropharynx
    Molecular Pathogenesis
    Nontypeable Haemophilus influenzae Invasive Blood Isolates Are Mainly Phosphorylcholine Negative and Show Decreased Complement-Mediated Killing That Is Associated with Lower Binding of IgM and CRP in Comparison to Colonizing Isolates from the Oropharynx

    Nontypeable Haemophilus influenzae (NTHi) bacteria express various molecules that contribute to their virulence. The presence of phosphocholine (PCho) on NTHi lipooligosaccharide increases adhesion to epithelial cells and is an advantage for the bacterium, enabling nasopharyngeal colonization, as measured in humans and animal models.

    Jeroen D. Langereis, Amelieke J. H. Cremers, Marloes Vissers, Josine van Beek, Jacques F. Meis, Marien I. de Jonge
  • Autoinducer 2 (AI-2) Production by Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> 86-028NP Promotes Expression of a Predicted Glycosyltransferase That Is a Determinant of Biofilm Maturation, Prevention of Dispersal, and Persistence <em>In Vivo</em>
    Host-Associated Microbial Communities
    Autoinducer 2 (AI-2) Production by Nontypeable Haemophilus influenzae 86-028NP Promotes Expression of a Predicted Glycosyltransferase That Is a Determinant of Biofilm Maturation, Prevention of Dispersal, and Persistence In Vivo

    Nontypeable Haemophilus influenzae (NTHi) is an extremely common human pathobiont that persists on the airway mucosal surface within biofilm communities, and our previous work has shown that NTHi biofilm maturation is coordinated by the production and uptake of autoinducer 2 (AI-2) quorum signals. To directly test roles for AI-2 in maturation and...

    Bing Pang, Chelsie E. Armbruster, Gayle Foster, Brian S. Learman, Uma Gandhi, W. Edward Swords
  • Bacterial Infections
    Otitis Media and Nasopharyngeal Colonization in ccl3−/− Mice
    Dominik Deniffel, Brian Nuyen, Kwang Pak, Keigo Suzukawa, Jun Hung, Arwa Kurabi, Stephen I. Wasserman, Allen F. Ryan

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