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IgM

  • Antibody Binding and Complement-Mediated Killing of Invasive <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> Isolates from Spain, Portugal, and the Netherlands
    Molecular Pathogenesis
    Antibody Binding and Complement-Mediated Killing of Invasive Haemophilus influenzae Isolates from Spain, Portugal, and the Netherlands

    Haemophilus influenzae is a Gram-negative bacterium that can be classified into typeable (types a through f) and nontypeable (NTHi) groups. This opportunistic pathogen asymptomatically colonizes the mucosal epithelium of the upper respiratory tract, from where it spreads to other neighboring regions, potentially leading to disease. Infection with NTHi can cause otitis...

    Elena Dudukina, Laura de Smit, Giel J. A. Verhagen, Arie van de Ende, José María Marimón, Paula Bajanca-Lavado, Carmen Ardanuy, Sara Marti, Marien I. de Jonge, Jeroen D. Langereis
  • Antibodies and Protection in Systemic <em>Salmonella</em> Infections: Do We Still Have More Questions than Answers?
    Minireview
    Antibodies and Protection in Systemic Salmonella Infections: Do We Still Have More Questions than Answers?

    Salmonella causes grave systemic infections in humans and other animals and provides a paradigm for other diseases in which the bacteria have both intracellular and extracellular lifestyles. New generations of vaccines rely on the essential contribution of the antibody responses for their protection. The quality, antigen specificity, and functions associated with...

    Pietro Mastroeni, Omar Rossi
  • Human IgM Inhibits the Formation of Titan-Like Cells in <span class="named-content genus-species" id="named-content-1">Cryptococcus neoformans</span>
    Fungal and Parasitic Infections
    Human IgM Inhibits the Formation of Titan-Like Cells in Cryptococcus neoformans

    Human studies have shown associations between cryptococcal meningitis and reduced IgM memory B cell levels, and studies in IgM- and/or B cell-deficient mice have demonstrated increased Cryptococcus neoformans dissemination from lungs to brain. Since immunoglobulins are part of the immune milieu that C....

    Nuria Trevijano-Contador, Kaila M. Pianalto, Connie B. Nichols, Oscar Zaragoza, J. Andrew Alspaugh, Liise-anne Pirofski
  • Survival of <span class="named-content genus-species" id="named-content-1">Streptococcus suis</span> in Porcine Blood Is Limited by the Antibody- and Complement-Dependent Oxidative Burst Response of Granulocytes
    Host Response and Inflammation
    Survival of Streptococcus suis in Porcine Blood Is Limited by the Antibody- and Complement-Dependent Oxidative Burst Response of Granulocytes

    Bacteremia is a hallmark of invasive Streptococcus suis infections of pigs, often leading to septicemia, meningitis, or arthritis. An important defense mechanism of neutrophils is the generation of reactive oxygen species (ROS). In this study, we report high levels of ROS production by blood granulocytes after intravenous infection of a pig with high levels of...

    Viktoria Rungelrath, Sophie Öhlmann, Gottfried Alber, Wieland Schrödl, Maren von Köckritz-Blickwede, Nicole de Buhr, Alexander Martens, Christoph Georg Baums, Nicole Schütze
  • Underlying Glycans Determine the Ability of Sialylated Lipooligosaccharide To Protect Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> from Serum IgM and Complement
    Molecular Pathogenesis
    Underlying Glycans Determine the Ability of Sialylated Lipooligosaccharide To Protect Nontypeable Haemophilus influenzae from Serum IgM and Complement

    Nontypeable Haemophilus influenzae (NTHi) efficiently colonizes the human nasopharynx asymptomatically but also causes respiratory mucosal infections, including otitis media, sinusitis, and bronchitis. The lipooligosaccharide (LOS) on the cell surface of NTHi displays complex glycans that mimic host structures, allowing it to evade immune recognition. However, LOS...

    Mary Darby Jackson, Sandy M. Wong, Brian J. Akerley
  • Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable <em>Haemophilus influenzae</em> Increases Complement-Mediated Killing
    Molecular Pathogenesis
    Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable Haemophilus influenzae Increases Complement-Mediated Killing

    Nontypeable Haemophilus influenzae (NTHi) colonizes the human upper respiratory tract without causing disease symptoms, but it is also a major cause of upper and lower respiratory tract infections in children and elderly, respectively. NTHi synthesizes various molecules to decorate its lipooligosaccharide (LOS), which modulates the level of virulence.

    ...
    Jeroen D. Langereis, Eva S. van der Pasch, Marien I. de Jonge
  • Uptake of Sialic Acid by Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> Increases Complement Resistance through Decreasing IgM-Dependent Complement Activation
    Molecular Pathogenesis
    Uptake of Sialic Acid by Nontypeable Haemophilus influenzae Increases Complement Resistance through Decreasing IgM-Dependent Complement Activation

    Although nontypeable Haemophilus influenzae (NTHi) is a human-specific nasopharyngeal commensal bacterium, it also causes upper respiratory tract infections in children and lower respiratory tract infections in the elderly, resulting in frequent antibiotic use. The transition from symbiotic colonizing bacterium to opportunistic pathogen is not completely understood....

    Marjolein M. P. Oerlemans, Sam J. Moons, Jurriaan J. A. Heming, Thomas J. Boltje, Marien I. de Jonge, Jeroen D. Langereis
  • Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> Invasive Blood Isolates Are Mainly Phosphorylcholine Negative and Show Decreased Complement-Mediated Killing That Is Associated with Lower Binding of IgM and CRP in Comparison to Colonizing Isolates from the Oropharynx
    Molecular Pathogenesis
    Nontypeable Haemophilus influenzae Invasive Blood Isolates Are Mainly Phosphorylcholine Negative and Show Decreased Complement-Mediated Killing That Is Associated with Lower Binding of IgM and CRP in Comparison to Colonizing Isolates from the Oropharynx

    Nontypeable Haemophilus influenzae (NTHi) bacteria express various molecules that contribute to their virulence. The presence of phosphocholine (PCho) on NTHi lipooligosaccharide increases adhesion to epithelial cells and is an advantage for the bacterium, enabling nasopharyngeal colonization, as measured in humans and animal models.

    Jeroen D. Langereis, Amelieke J. H. Cremers, Marloes Vissers, Josine van Beek, Jacques F. Meis, Marien I. de Jonge
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