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IL-10

  • Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages
    Host Response and Inflammation
    Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages

    This study investigated responses to Toll-like receptor 2 (TLR2)-driven extracellular signal-related kinase (ERK) signaling in dendritic cells (DCs) versus macrophages. TLR2 signaling was induced with Pam3Cys-Ser-Lys4, and the role of ERK signaling was interrogated pharmacologically with MEK1/2 inhibitor U0126 or genetically with bone marrow-derived macrophages or DCs from Tpl2−/− mice. We...

    Sarah G. Groft, Nancy Nagy, W. Henry Boom, Clifford V. Harding
  • Interleukin-10 (IL-10) Produced by Mutant Toxic Shock Syndrome Toxin 1 Vaccine-Induced Memory T Cells Downregulates IL-17 Production and Abrogates the Protective Effect against <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Infection
    Microbial Immunity and Vaccines
    Interleukin-10 (IL-10) Produced by Mutant Toxic Shock Syndrome Toxin 1 Vaccine-Induced Memory T Cells Downregulates IL-17 Production and Abrogates the Protective Effect against Staphylococcus aureus Infection

    Development of long-term memory is crucial for vaccine-induced adaptive immunity against infectious diseases such as Staphylococcus aureus infection. Toxic shock syndrome toxin 1 (TSST-1), one of the superantigens produced by S. aureus, is a possible vaccine candidate against infectious diseases...

    Kouji Narita, Dong-Liang Hu, Krisana Asano, Akio Nakane
  • Host Response and Inflammation
    Potential Role for Regulatory B Cells as a Major Source of Interleukin-10 in Spleen from Plasmodium chabaudi-Infected Mice
    Xue Han, Ji Yang, Yitong Zhang, Yalin Zhang, Hongtao Cao, Yaming Cao, Zanmei Qi
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling
    Bikash Sahay, Kathleen Bashant, Nicole L. J. Nelson, Rebeca L. Patsey, Shiva Kumar Gadila, Rebecca Boohaker, Ashutosh Verma, Klemen Strle, Timothy J. Sellati
  • Open Access
    Fungal and Parasitic Infections | Spotlight
    Host Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling
    Carla Claser, J. Brian De Souza, Samuel G. Thorburn, Georges Emile Grau, Eleanor M. Riley, Laurent Rénia, Julius C. R. Hafalla
  • Host Response and Inflammation
    RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis
    Michael J. Noto, Kyle W. Becker, Kelli L. Boyd, Ann Marie Schmidt, Eric P. Skaar
  • Host Response and Inflammation
    Local Induction of B Cell Interleukin-10 Competency Alleviates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice
    Pei Yu, Yang Hu, Zhiqiang Liu, Toshihisa Kawai, Martin A. Taubman, Wei Li, Xiaozhe Han
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