infectious diseases

  • Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies
    Molecular Pathogenesis
    Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies

    Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5 architecture with two active subunits, the ADP ribosyl transferase PltA and the DNase CdtB, linked to a pentameric B subunit, which is alternatively made of...

    Xuyao Jiao, Sarah Smith, Gabrielle Stack, Qi Liang, Allan Bradley, Paul Kellam, Jorge E. Galán
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