inhibitor

  • PhiA, a Peptidoglycan Hydrolase Inhibitor of <em>Brucella</em> Involved in the Virulence Process
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    PhiA, a Peptidoglycan Hydrolase Inhibitor of Brucella Involved in the Virulence Process

    The peptidoglycan in Gram-negative bacteria is a dynamic structure in constant remodeling. This dynamism, achieved through synthesis and degradation, is essential because the peptidoglycan is necessary to maintain the structure of the cell but has to have enough plasticity to allow the transport and assembly of macromolecular complexes in the periplasm and outer membrane. In addition, this remodeling has to be coordinated with the...

    Mariela G. Del Giudice, Alexis M. Romani, Juan E. Ugalde, Cecilia Czibener
  • Open Access
    Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from <span class="named-content genus-species" id="named-content-1">Streptomyces goldiniensis</span>
    Bacterial Infections
    Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis

    Recent work has demonstrated that the polyketide natural product Aurodox from Streptomyces goldiniensis is able to block the pathogenesis of the murine pathogen Citrobacter rodentium. In this work, we aimed to gain a better understanding of the mechanism of action of the compound.

    ...
    Rebecca E. McHugh, Nicky O’Boyle, James P. R. Connolly, Paul A. Hoskisson, Andrew J. Roe
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