innate immunity
Host Response and InflammationDifferential Recognition of Vibrio parahaemolyticus OmpU by Toll-Like Receptors in Monocytes and Macrophages for the Induction of Proinflammatory ResponsesVibrio parahaemolyticus is a human pathogen, and it is a major cause of severe gastroenteritis in coastal areas. OmpU is one of the major outer membrane porins of V. parahaemolyticus.
Host Response and Inflammation | SpotlightA Phenome-Wide Association Study Uncovers a Pathological Role of Coagulation Factor X during Acinetobacter baumannii InfectionCoagulation and inflammation are interconnected, suggesting that coagulation plays a key role in the inflammatory response to pathogens. A phenome-wide association study (PheWAS) was used to identify clinical phenotypes of patients with a polymorphism in coagulation factor X.
Host Response and InflammationDepletion of Complement Enhances the Clearance of Brucella abortus in MiceBrucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement.
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsCoxiella burnetii Blocks Intracellular Interleukin-17 Signaling in MacrophagesCoxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole membrane into the host cytoplasm, where they...
- Fungal and Parasitic Infections | SpotlightThe Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus
- Fungal and Parasitic Infections | SpotlightMyeloid Differentiation Factor 88 and Interleukin-1R1 Signaling Contribute to Resistance to Coccidioides immitis
- Host Response and InflammationThioester-Containing Proteins 2 and 4 Affect the Metabolic Activity and Inflammation Response in Drosophila
- Bacterial InfectionsA Natural Mouse Model for Neisseria Colonization
- Host Response and InflammationNeutrophils from Both Susceptible and Resistant Mice Efficiently Kill Opsonized Listeria monocytogenes