interleukin-17
Host Response and Inflammation | SpotlightRegulation of Pulmonary Bacterial Immunity by Follistatin-Like Protein 1Klebsiella pneumoniae is a common cause of antibiotic-resistant pneumonia. Follistatin-like protein 1 (FSTL-1) is highly expressed in the lung and is critical for lung homeostasis. The role of FSTL-1 in immunity to bacterial pneumonia is unknown. Wild-type (WT) and FSTL-1 hypomorphic (Hypo) mice were infected with...
Host Response and InflammationInterleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to Helicobacter pylori and Modulates T Lymphocyte IL-17A Expression in Peyer’s Patches during InfectionInterleukin-21 (IL-21), a cytokine produced by many subsets of activated immune cells, is critical for driving inflammation in several models. Using Helicobacter pylori infection as a model for chronic mucosal infection, we previously published that IL-21 is required for the development of gastritis in response to infection. Concomitant with protection from chronic...
Host Response and InflammationGamma Interferon and Interleukin-17A Differentially Influence the Response of Human Macrophages and Neutrophils to Pseudomonas aeruginosa InfectionMacrophages are important orchestrators of inflammation during bacterial infection, acting as both effector cells and regulators of neutrophil recruitment and life span. Differently activated macrophage populations with distinct inflammatory and microbicidal potentials have been described.
- Microbial Immunity and VaccinesTh17-Mediated Cross Protection against Pneumococcal Carriage by Vaccination with a Variable Antigen
- Host Response and InflammationInterleukin-17C in Human Helicobacter pylori Gastritis
- Fungal and Parasitic Infections | SpotlightPulmonary Interleukin-17-Positive Lymphocytes Increase during Pneumocystis murina Infection but Are Not Required for Clearance of Pneumocystis
- Fungal and Parasitic InfectionsInterleukin-17-Mediated Control of Parasitemia in Experimental Trypanosoma congolense Infection in Mice