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Infection and Immunity
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interleukin-17

  • Regulation of Pulmonary Bacterial Immunity by Follistatin-Like Protein 1
    Host Response and Inflammation | Spotlight
    Regulation of Pulmonary Bacterial Immunity by Follistatin-Like Protein 1

    Klebsiella pneumoniae is a common cause of antibiotic-resistant pneumonia. Follistatin-like protein 1 (FSTL-1) is highly expressed in the lung and is critical for lung homeostasis. The role of FSTL-1 in immunity to bacterial pneumonia is unknown. Wild-type (WT) and FSTL-1 hypomorphic (Hypo) mice were infected with...

    Matthew Henkel, Justin A. Dutta, Jessica Partyka, Taylor Eddens, Raphael Hirsch, Jay K. Kolls, Brian T. Campfield
  • Interleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to <span class="named-content genus-species" id="named-content-1">Helicobacter pylori</span> and Modulates T Lymphocyte IL-17A Expression in Peyer’s Patches during Infection
    Host Response and Inflammation
    Interleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to Helicobacter pylori and Modulates T Lymphocyte IL-17A Expression in Peyer’s Patches during Infection

    Interleukin-21 (IL-21), a cytokine produced by many subsets of activated immune cells, is critical for driving inflammation in several models. Using Helicobacter pylori infection as a model for chronic mucosal infection, we previously published that IL-21 is required for the development of gastritis in response to infection. Concomitant with protection from chronic...

    Sharia Yasmin, Beverly R. E. A. Dixon, Danyvid Olivares-Villagómez, Holly M. Scott Algood
  • Open Access
    Gamma Interferon and Interleukin-17A Differentially Influence the Response of Human Macrophages and Neutrophils to <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Infection
    Host Response and Inflammation
    Gamma Interferon and Interleukin-17A Differentially Influence the Response of Human Macrophages and Neutrophils to Pseudomonas aeruginosa Infection

    Macrophages are important orchestrators of inflammation during bacterial infection, acting as both effector cells and regulators of neutrophil recruitment and life span. Differently activated macrophage populations with distinct inflammatory and microbicidal potentials have been described.

    Sirina Muntaka, Yasir Almuhanna, Darryl Jackson, Sonali Singh, Afrakoma Afryie-Asante, Miguel Cámara, Luisa Martínez-Pomares
  • Fungal and Parasitic Infections
    Interleukin-17A-Deficient Mice Are Highly Susceptible to Toxoplasma gondii Infection Due to Excessively Induced T. gondii HSP70 and Interferon Gamma Production
    Masataka Moroda, Masaya Takamoto, Yoichiro Iwakura, Jun Nakayama, Fumie Aosai
  • Microbial Immunity and Vaccines
    Th17-Mediated Cross Protection against Pneumococcal Carriage by Vaccination with a Variable Antigen
    Kirsten Kuipers, Wouter S. P. Jong, Christa E. van der Gaast-de Jongh, Diane Houben, Fred van Opzeeland, Elles Simonetti, Saskia van Selm, Ronald de Groot, Marije I. Koenders, Taj Azarian, Elder Pupo, Peter van der Ley, Jeroen D. Langereis, Aldert Zomer, Joen Luirink, Marien I. de Jonge
  • Host Response and Inflammation
    Interleukin-17C in Human Helicobacter pylori Gastritis
    Shingo Tanaka, Hiroyuki Nagashima, Modesto Cruz, Tomohisa Uchida, Takahiro Uotani, José A. Jiménez Abreu, Varocha Mahachai, Ratha-korn Vilaichone, Thawee Ratanachu-ek, Lotay Tshering, David Y. Graham, Yoshio Yamaoka
  • Host Response and Inflammation
    Interleukin-17A Aggravates Middle Ear Injury Induced by Streptococcus pneumoniae through the p38 Mitogen-Activated Protein Kinase Signaling Pathway
    Wei Wang, Wenbin Liu, Jiali Liu, Zimeng Wang, Fangmei Fan, Yurong Ma, Chunfang Jin, Yun Xiang, Yifei Huang, Xuemei Zhang, Wenchun Xu, Yibing Yin, Yujuan He
  • Free
    Fungal and Parasitic Infections | Spotlight
    Pulmonary Interleukin-17-Positive Lymphocytes Increase during Pneumocystis murina Infection but Are Not Required for Clearance of Pneumocystis
    Chiara Ripamonti, Lisa R. Bishop, Joseph A. Kovacs
  • Fungal and Parasitic Infections
    Interleukin-17 Is Not Required for Classical Macrophage Activation in a Pulmonary Mouse Model of Cryptococcus neoformans Infection
    Sarah E. Hardison, Karen L. Wozniak, Jay K. Kolls, Floyd L. Wormley
  • Fungal and Parasitic Infections
    Interleukin-17-Mediated Control of Parasitemia in Experimental Trypanosoma congolense Infection in Mice
    Zhirong Mou, Ping Jia, Shiby Kuriakose, Forough Khadem, Jude E. Uzonna

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