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Infection and Immunity
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iron

  • The <span class="named-content genus-species" id="named-content-1">Serratia marcescens</span> Siderophore Serratiochelin Is Necessary for Full Virulence during Bloodstream Infection
    Bacterial Infections | Spotlight
    The Serratia marcescens Siderophore Serratiochelin Is Necessary for Full Virulence during Bloodstream Infection

    Serratia marcescens is a bacterium frequently found in the environment, but over the last several decades it has evolved into a concerning clinical pathogen, causing fatal bacteremia. To establish such infections, pathogens require specific nutrients; one very limited but essential nutrient is iron. We sought to characterize the iron acquisition systems in...

    Danelle R. Weakland, Sara N. Smith, Bailey Bell, Ashootosh Tripathi, Harry L. T. Mobley
  • PPE37 Is Essential for <em>Mycobacterium tuberculosis</em> Heme-Iron Acquisition (HIA), and a Defective PPE37 in <em>Mycobacterium bovis</em> BCG Prevents HIA
    Molecular Pathogenesis
    PPE37 Is Essential for Mycobacterium tuberculosis Heme-Iron Acquisition (HIA), and a Defective PPE37 in Mycobacterium bovis BCG Prevents HIA

    Mycobacterium tuberculosis, one of the world’s leading causes of death, must acquire nutrients, such as iron, from the host to multiply and cause disease. Iron is an essential metal and M. tuberculosis possesses two different systems to acquire iron from its environment: siderophore-mediated iron...

    Michael V. Tullius, Susana Nava, Marcus A. Horwitz
  • Bacterial Infections | Spotlight
    Malaria Parasite-Mediated Alteration of Macrophage Function and Increased Iron Availability Predispose to Disseminated Nontyphoidal Salmonella Infection

    Disseminated infections with nontyphoidal Salmonella (NTS) are a significant cause of child mortality in sub-Saharan Africa. NTS infection in children is clinically associated with malaria, suggesting that malaria compromises the control of disseminated NTS infection.

    Kristen L. Lokken, Annica R. Stull-Lane, Kikkie Poels, Renée M. Tsolis
  • Host Response and Inflammation
    Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients
    Deborah Stefanova, Antoan Raychev, Jaime Deville, Romney Humphries, Shelley Campeau, Piotr Ruchala, Elizabeta Nemeth, Tomas Ganz, Yonca Bulut
  • Open Access
    Host Response and Inflammation
    Role of Activins in Hepcidin Regulation during Malaria
    Natasha Spottiswoode, Andrew E. Armitage, Andrew R. Williams, Alex J. Fyfe, Sumi Biswas, Susanne H. Hodgson, David Llewellyn, Prateek Choudhary, Simon J. Draper, Patrick E. Duffy, Hal Drakesmith
  • Bacterial Infections
    In Vivo Analysis of Staphylococcus aureus-Infected Mice Reveals Differential Temporal and Spatial Expression Patterns of fhuD2
    Marta Bacconi, Andreas F. Haag, Emiliano Chiarot, Paolo Donato, Fabio Bagnoli, Isabel Delany, Giuliano Bensi
  • Host Response and Inflammation
    Hepcidin-(In)dependent Mechanisms of Iron Metabolism Regulation during Infection by Listeria and Salmonella
    Ana C. Moreira, João V. Neves, Tânia Silva, Patrícia Oliveira, Maria S. Gomes, Pedro N. Rodrigues
  • Molecular Pathogenesis
    Association of Metal Homeostasis and (p)ppGpp Regulation in the Pathophysiology of Enterococcus faecalis
    C. Colomer-Winter, A. O. Gaca, J. A. Lemos
  • Free
    Bacterial Infections | Spotlight
    The PerR-Regulated P1B-4-Type ATPase (PmtA) Acts as a Ferrous Iron Efflux Pump in Streptococcus pyogenes
    Andrew G. Turner, Cheryl-lynn Y. Ong, Karrera Y. Djoko, Nicholas P. West, Mark R. Davies, Alastair G. McEwan, Mark J. Walker
  • Bacterial Infections
    The Suf Iron-Sulfur Cluster Biosynthetic System Is Essential in Staphylococcus aureus, and Decreased Suf Function Results in Global Metabolic Defects and Reduced Survival in Human Neutrophils
    Christina A. Roberts, Hassan M. Al-Tameemi, Ameya A. Mashruwala, Zuelay Rosario-Cruz, Unnati Chauhan, William E. Sause, Victor J. Torres, William J. Belden, Jeffrey M. Boyd

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