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Infection and Immunity
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Leishmania major

  • Open Access
    Deletion of Interleukin-4 Receptor Alpha-Responsive Keratinocytes in BALB/c Mice Does Not Alter Susceptibility to Cutaneous Leishmaniasis
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Deletion of Interleukin-4 Receptor Alpha-Responsive Keratinocytes in BALB/c Mice Does Not Alter Susceptibility to Cutaneous Leishmaniasis

    The skin microenvironment at the site of infection plays a role in the early events that determine protective T helper 1/type 1 immune responses during cutaneous leishmaniasis (CL) infection. During CL in nonhealing BALB/c mice, early interleukin-4 (IL-4) can instruct dendritic cells for protective Th1 immunity.

    Melissa Govender, Ramona Hurdayal, Berenice Martinez-Salazar, Kaya Gqada, Shandre Pillay, Lorna Gcanga, Katiuska Passelli, Natalie E. Nieuwenhuizen, Fabienne Tacchini-Cottier, Reto Guler, Frank Brombacher
  • Fungal and Parasitic Infections
    Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway
    Sabine Leitherer, Joachim Clos, Elisabeth M. Liebler-Tenorio, Ulrike Schleicher, Christian Bogdan, Didier Soulat
  • Host Response and Inflammation
    Fine Mapping of Leishmania major Susceptibility Locus lmr2 and Evidence of a Role for Fli1 in Disease and Wound Healing
    Anuratha Sakthianandeswaren, Joan M. Curtis, Colleen Elso, Beena Kumar, Tracey M. Baldwin, Sash Lopaticki, Lukasz Kedzierski, Gordon K. Smyth, Simon J. Foote, Emanuela Handman
  • Fungal and Parasitic Infections
    Upregulated Expression of B-Cell Antigen Family Tandem Repeat Proteins by Leishmania Amastigotes
    Yasuyuki Goto, Darrick Carter, Jeffrey Guderian, Noboru Inoue, Shin-Ichiro Kawazu, Steven G. Reed
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Complement Receptor 3 Deficiency Influences Lesion Progression during Leishmania major Infection in BALB/c Mice
    Cristina R. Carter, James P. Whitcomb, Jessica A. Campbell, Rami M. Mukbel, Mary Ann McDowell
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Leishmania major Phosphoglycans Influence the Host Early Immune Response by Modulating Dendritic Cell Functions
    Dong Liu, Chahnaz Kebaier, Nazzy Pakpour, Althea A. Capul, Stephen M. Beverley, Phillip Scott, Jude E. Uzonna
  • Fungal and Parasitic Infections
    The Absence of Cutaneous Lymph Nodes Results in a Th2 Response and Increased Susceptibility to Leishmania major Infection in Mice
    Jan M. Ehrchen, Johannes Roth, Kirsten Roebrock, Georg Varga, Wolfram Domschke, Rodney Newberry, Clemens Sorg, Carsten Müller-Tidow, Cord Sunderkötter, Torsten Kucharzik, Thomas W. Spahn
  • Microbial Immunity and Vaccines
    Immunization with a Toll-Like Receptor 7 and/or 8 Agonist Vaccine Adjuvant Increases Protective Immunity against Leishmania major in BALB/c Mice
    Wen-Wei Zhang, Greg Matlashewski
  • Fungal and Parasitic Infections
    Leishmania major Infection Activates NF-κB and Interferon Regulatory Factors 1 and 8 in Human Dendritic Cells
    Asha Jayakumar, Michael J. Donovan, Vinita Tripathi, Marcelo Ramalho-Ortigao, Mary Ann McDowell
  • Fungal and Parasitic Infections
    Comparison of the Effects of Leishmania major or Leishmania donovani Infection on Macrophage Gene Expression
    David J. Gregory, Robert Sladek, Martin Olivier, Greg Matlashewski

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