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Infection and Immunity
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  • Differential Induction of Type I and III Interferons by <em>Staphylococcus aureus</em>
    Host Response and Inflammation | Spotlight
    Differential Induction of Type I and III Interferons by Staphylococcus aureus

    Staphylococcus aureus is a leading cause of bacterial pneumonia, and we have shown previously that type I interferon (IFN) contributes to the pathogenesis of this disease. In this study, we screened 75 S. aureus strains for their ability to induce type I and III IFN. Both cytokine pathways were...

    Adeline Peignier, Paul J. Planet, Dane Parker
  • Transbronchial Invasion and Proliferation of <span class="named-content genus-species" id="named-content-1">Leptospira interrogans</span> in Lung without Inflammatory Cell Infiltration in a Hamster Model
    Host Response and Inflammation
    Transbronchial Invasion and Proliferation of Leptospira interrogans in Lung without Inflammatory Cell Infiltration in a Hamster Model

    Leptospirosis caused by pathogenic Leptospira is one of the most common zoonoses in the world. It is believed that humans become infected with it mainly through their skin and mucous membranes by contact with water or soil that is contaminated with urine excreted from infected animals. Recently, outbreaks have frequently occurred in the tropics, especially after flooding, but how leptospires cause mass infection remains poorly...

    Yasuhiko Nikaido, Midori Ogawa, Kazumasa Fukuda, Mitsuru Yokoyama, Takaaki Kanemaru, Toshiyuki Nakayama, Mitsumasa Saito
  • Role of Common γ-Chain Cytokines in Lung Interleukin-22 Regulation after Acute Exposure to <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span>
    Host Response and Inflammation | Spotlight
    Role of Common γ-Chain Cytokines in Lung Interleukin-22 Regulation after Acute Exposure to Aspergillus fumigatus

    Humans are constantly exposed to the opportunistic mold Aspergillus fumigatus, and disease caused by this pathogen is often determined by the magnitude of local and systemic immune responses. We have previously shown a protective role for interleukin-22 (IL-22) after acute A. fumigatus exposure....

    Kristen M. Reeder, Joseph J. Mackel, Matthew S. Godwin, Chad W. Dunaway, Jonathan P. Blackburn, Rakesh P. Patel, Chad Steele
  • Fungal and Parasitic Infections
    Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis That Amplifies Regulatory T Cells in a Pulmonary Fungal Infection
    Jamie L. Tweedle, George S. Deepe
  • Free
    Host Response and Inflammation | Spotlight
    Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates
    Alayna K. Caffrey-Carr, Caitlin H. Kowalski, Sarah R. Beattie, Nathan A. Blaseg, Chanell R. Upshaw, Arsa Thammahong, Hannah E. Lust, Yi-Wei Tang, Tobias M. Hohl, Robert A. Cramer, Joshua J. Obar
  • Open Access
    Host Response and Inflammation | Spotlight
    Killing of Pseudomonas aeruginosa by Chicken Cathelicidin-2 Is Immunogenically Silent, Preventing Lung Inflammation In Vivo
    Maarten Coorens, Brandon J. H. Banaschewski, Brandon J. Baer, Cory Yamashita, Albert van Dijk, Henk P. Haagsman, Ruud A. W. Veldhuizen, Edwin J. A. Veldhuizen
  • Bacterial Infections
    Fatal Pertussis in the Neonatal Mouse Model Is Associated with Pertussis Toxin-Mediated Pathology beyond the Airways
    Karen M. Scanlon, Yael G. Snyder, Ciaran Skerry, Nicholas H. Carbonetti
  • Host Response and Inflammation
    Cytosolic Phospholipase A2α Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection
    Rudra Bhowmick, Stacie Clark, Joseph V. Bonventre, John M. Leong, Beth A. McCormick
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Immune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa
    Damien Roux, Molly Weatherholt, Bradley Clark, Mihaela Gadjeva, Diane Renaud, David Scott, David Skurnik, Gregory P. Priebe, Gerald Pier, Craig Gerard, Deborah R. Yoder-Himes
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic Pneumonia
    Cao Li, Yuqing Wu, Andrea Riehle, Jie Ma, Markus Kamler, Erich Gulbins, Heike Grassmé

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