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Infection and Immunity
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lung infection

  • Role of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Glutathione Biosynthesis in Lung and Soft Tissue Infection
    Bacterial Infections
    Role of Pseudomonas aeruginosa Glutathione Biosynthesis in Lung and Soft Tissue Infection

    The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of morbidity and mortality worldwide. To survive in both the environment and the host, P. aeruginosa must cope with redox stress. In P. aeruginosa, a primary...

    Kelly L. Michie, Justine L. Dees, Derek Fleming, Dina A. Moustafa, Joanna B. Goldberg, Kendra P. Rumbaugh, Marvin Whiteley
  • Transposon Mutagenesis Screen of <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> Identifies Multiple Genes Important for Resisting Antimicrobial Activities of Neutrophils in Mice
    Molecular Pathogenesis
    Transposon Mutagenesis Screen of Klebsiella pneumoniae Identifies Multiple Genes Important for Resisting Antimicrobial Activities of Neutrophils in Mice

    Klebsiella pneumoniae is a Gram-negative bacterial pathogen that causes a range of infections, including pneumonias, urinary tract infections, and septicemia, in otherwise healthy and immunocompromised patients. K. pneumoniae has become an increasing concern due to the rise and spread of antibiotic-...

    Michelle K. Paczosa, Rebecca J. Silver, Anne L. McCabe, Albert K. Tai, Colin H. McLeish, David W. Lazinski, Joan Mecsas
  • Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute <em>Streptococcus pneumoniae</em> Pneumonia
    Host Response and Inflammation
    Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute Streptococcus pneumoniae Pneumonia

    Neutrophils contribute to lung injury in acute pneumococcal pneumonia. The interleukin 17 receptor E (IL-17RE) is the functional receptor for the epithelial-derived cytokine IL-17C, which is known to mediate innate immune functions. The aim of this study was to investigate the contribution of IL-17RE/IL-17C to pulmonary inflammation in a mouse model of acute Streptococcus...

    Patrick Steck, Felix Ritzmann, Anja Honecker, Giovanna Vella, Christian Herr, Rosmarie Gaupp, Markus Bischoff, Timotheus Speer, Thomas Tschernig, Robert Bals, Christoph Beisswenger
  • Open Access
    Characterization of Host Responses during <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Acute Infection in the Lungs and Blood and after Treatment with the Synthetic Immunomodulatory Peptide IDR-1002
    Host Response and Inflammation
    Characterization of Host Responses during Pseudomonas aeruginosa Acute Infection in the Lungs and Blood and after Treatment with the Synthetic Immunomodulatory Peptide IDR-1002

    Pseudomonas aeruginosa is an opportunistic pathogen that causes nosocomial pneumonia and infects patients with cystic fibrosis. P. aeruginosa lung infections are difficult to treat due to bacterial resistance to antibiotics, and strains with multidrug resistance are becoming more prevalent.

    ...
    Kelli Wuerth, Amy H. Y. Lee, Reza Falsafi, Erin E. Gill, Robert E. W. Hancock
  • Host Response and Inflammation
    Interleukin-17A Exacerbates Disease Severity in BALB/c Mice Susceptible to Lung Infection with Mycoplasma pulmonis

    Mycoplasmas are atypical bacteria that disrupt the immune response to promote respiratory tract infections and secondary complications. However, not every immunologic response that protects or damages the host during mycoplasma infection is known.

    Maximillion T. Mize, Xiangle L. Sun, Jerry W. Simecka
  • Fungal and Parasitic Infections
    Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis That Amplifies Regulatory T Cells in a Pulmonary Fungal Infection
    Jamie L. Tweedle, George S. Deepe
  • Microbial Immunity and Vaccines
    Detrimental Influence of Alveolar Macrophages on Protective Humoral Immunity during Francisella tularensis SchuS4 Pulmonary Infection
    Donald J. Steiner, Yoichi Furuya, Dennis W. Metzger
  • Free
    Host Response and Inflammation | Spotlight
    Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates
    Alayna K. Caffrey-Carr, Caitlin H. Kowalski, Sarah R. Beattie, Nathan A. Blaseg, Chanell R. Upshaw, Arsa Thammahong, Hannah E. Lust, Yi-Wei Tang, Tobias M. Hohl, Robert A. Cramer, Joshua J. Obar
  • Microbial Immunity and Vaccines
    Protective Role for Macrophages in Respiratory Francisella tularensis Infection
    Donald J. Steiner, Yoichi Furuya, Michael B. Jordan, Dennis W. Metzger
  • Bacterial Infections
    Filamentous Bacteriophage Produced by Pseudomonas aeruginosa Alters the Inflammatory Response and Promotes Noninvasive Infection In Vivo
    Patrick R. Secor, Lia A. Michaels, Kate S. Smigiel, Maryam G. Rohani, Laura K. Jennings, Katherine B. Hisert, Allison Arrigoni, Kathleen R. Braun, Timothy P. Birkland, Ying Lai, Teal S. Hallstrand, Paul L. Bollyky, Pradeep K. Singh, William C. Parks
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